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Literature summary for 1.4.3.21 extracted from

  • ORourke, A.M.; Wang, E.Y.; Miller, A.; Podar, E.M.; Scheyhing, K.; Huang, L.; Kessler, C.; Gao, H.; Ton-Nu, H.T.; Macdonald, M.T.; Jones, D.S.; Linnik, M.D.
    Anti-inflammatory effects of LJP 1586 [Z-3-fluoro-2-(4-methoxybenzyl)allylamine hydrochloride], an amine-based inhibitor of semicarbazide-sensitive amine oxidase activity (2008), J. Pharmacol. Exp. Ther., 324, 867-875.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
(Z)-3-fluoro-2-(4-methoxybenzyl)allylamine hydrochloride i.e. LJP 1586. Potent, specific, and orally available inhibitor of SSAO activity is an effective anti-inflammatory compound in vivo Homo sapiens
(Z)-3-fluoro-2-(4-methoxybenzyl)allylamine hydrochloride i.e. LJP 1586. Potent, specific, and orally available inhibitor of SSAO activity is an effective anti-inflammatory compound in vivo Mus musculus
(Z)-3-fluoro-2-(4-methoxybenzyl)allylamine hydrochloride i.e. LJP 1586. Potent, specific, and orally available inhibitor of SSAO activity is an effective anti-inflammatory compound in vivo Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta
-
 Mus musculus
-
lung
-
 Rattus norvegicus
-
umbilical cord
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzylamine + H2O + O2
-
 Mus musculus benzaldehyde + NH3 + H2O2
-
 ?
benzylamine + H2O + O2
-
 Homo sapiens benzaldehyde + NH3 + H2O2
-
 ?
benzylamine + H2O + O2
-
 Rattus norvegicus benzaldehyde + NH3 + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
SSAO
-
 Mus musculus
SSAO
-
 Homo sapiens
SSAO
-
 Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000004
-
-
 Mus musculus (Z)-3-fluoro-2-(4-methoxybenzyl)allylamine hydrochloride
0.000009
-
-
 Rattus norvegicus (Z)-3-fluoro-2-(4-methoxybenzyl)allylamine hydrochloride
0.000027
-
 enzyme from umbilical cord Homo sapiens (Z)-3-fluoro-2-(4-methoxybenzyl)allylamine hydrochloride
0.000043
-
 lysates of human SSAO-expressing CHO cells Homo sapiens (Z)-3-fluoro-2-(4-methoxybenzyl)allylamine hydrochloride