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Literature summary for 1.4.3.21 extracted from

  • Nunes, S.F.; Figueiredo, I.V.; Soares, P.J.; Costa, N.E.; Lopes, M.C.; Caramona, M.M.
    Semicarbazide-sensitive amine oxidase activity and total nitrite and nitrate concentrations in serum: novel biochemical markers for type 2 diabetes? (2009), Acta Diabetol., 46, 135-140.
    View publication on PubMed
Search for more literature for 1.4.3.21

Metals/Ions

Metals/Ions Comment Organism Structure
copper dependent on Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
aminoacetone + H2O + O2 Homo sapiens
-
 methylglyoxal + NH3 + H2O2
-
 ?
methylamine + H2O + O2 Homo sapiens
-
 formaldehyde + NH3 + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipocyte
-
 Homo sapiens
-
eye
-
 Homo sapiens
-
heart
-
 Homo sapiens
-
kidney
-
 Homo sapiens
-
liver
-
 Homo sapiens
-
lung
-
 Homo sapiens
-
pancreas
-
 Homo sapiens
-
placenta
-
 Homo sapiens
-
serum significantly elevated serum SSAO activity in diabetic patients, overview Homo sapiens
-
vascular smooth muscle cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
aminoacetone + H2O + O2
-
 Homo sapiens methylglyoxal + NH3 + H2O2
-
 ?
benzylamine + H2O + O2
-
 Homo sapiens benzaldehyde + NH3 + H2O2
-
 ?
methylamine + H2O + O2
-
 Homo sapiens formaldehyde + NH3 + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
semicarbazide-sensitive amine oxidase
-
 Homo sapiens
SSAO
-
 Homo sapiens
VAP-1
-
 Homo sapiens
vascular adhesion protein-1
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
2,4,5-trihydroxyphenylalaninequinone i.e. TPQ cofactor Homo sapiens

General Information

General Information Comment Organism
physiological function SSAO is also known as vascular adhesion protein-1 and acts as one of the adhesion molecules involved in lymphocytes trafficking. Increased serum SSAO/VAP-1 mediates tissue-selective lymphocyte adhesion and thus it may be involved in inflammatory liver cirrhosis and congestive heart failure Homo sapiens