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Literature summary for 1.4.3.21 extracted from

  • Murakawa, T.; Hayashi, H.; Taki, M.; Yamamoto, Y.; Kawano, Y.; Tanizawa, K.; Okajima, T.
    Structural insights into the substrate specificity of bacterial copper amine oxidase obtained by using irreversible inhibitors (2012), J. Biochem., 151, 167-178.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli CD03 cells Arthrobacter globiformis

Crystallization (Commentary)

Crystallization (Comment) Organism
complexed with benzylhydrazine, 4-hydroxybenzylhydrazine and phenylhydrazine, micro dialysis method, using 1.05 M potassium sodium tartrate in 25mM HEPES buffer, pH 6.8, at 16°C Arthrobacter globiformis

Inhibitors

Inhibitors Comment Organism Structure
4-hydroxybenzylhydrazine
-
Arthrobacter globiformis
benzylhydrazine
-
Arthrobacter globiformis
phenylhydrazine
-
Arthrobacter globiformis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0025
-
2-Phenylethylamine in 50mM HEPES buffer, pH 6.8, at 15°C Arthrobacter globiformis
0.0104
-
tyramine in 50mM HEPES buffer, pH 6.8, at 15°C Arthrobacter globiformis
0.1
-
benzylamine in 50mM HEPES buffer, pH 6.8, at 15°C Arthrobacter globiformis

Organism

Organism UniProt Comment Textmining
Arthrobacter globiformis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-phenylethylamine + H2O + O2 preferred substrate Arthrobacter globiformis phenylacetaldehyde + NH3 + H2O2
-
?
benzylamine + H2O + O2 very poor substrate Arthrobacter globiformis benzaldehyde + NH3 + H2O2
-
?
tyramine + H2O + O2 preferred substrate Arthrobacter globiformis (4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
?

Synonyms

Synonyms Comment Organism
CAO
-
Arthrobacter globiformis
Copper amine oxidase
-
Arthrobacter globiformis

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.24
-
benzylamine in 50mM HEPES buffer, pH 6.8, at 15°C Arthrobacter globiformis
35
-
tyramine in 50mM HEPES buffer, pH 6.8, at 15°C Arthrobacter globiformis
44
-
2-Phenylethylamine in 50mM HEPES buffer, pH 6.8, at 15°C Arthrobacter globiformis

Cofactor

Cofactor Comment Organism Structure
2,4,5-trihydroxyphenylalanine quinone
-
Arthrobacter globiformis