Inhibitors | Comment | Organism | Structure |
---|---|---|---|
aminoguanidine | - |
Canis lupus familiaris | |
aminoguanidine | - |
Cavia porcellus | |
aminoguanidine | 0.00001 mM, 50% inhibition, putrescine or histamine as substrates | Homo sapiens | |
aminoguanidine | - |
Mus musculus | |
aminoguanidine | - |
Oryctolagus cuniculus | |
aminoguanidine | - |
Rattus norvegicus | |
aminoguanidine | - |
Sus scrofa |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.019 | - |
histamine | - |
Homo sapiens | |
0.083 | - |
putrescine | - |
Homo sapiens | |
0.097 | - |
N(tau)-methylhistamine | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Sus scrofa | 5737 | - |
cytoplasm | - |
Canis lupus familiaris | 5737 | - |
cytoplasm | mainly in cytoplasm but to a considerable extent also in mitochondrial fraction | Mus musculus | 5737 | - |
cytoplasm | mainly in cytoplasm but to a considerable extent also in mitochondrial fraction | Homo sapiens | 5737 | - |
cytoplasm | mainly in cytoplasm but to a considerable extent also in mitochondrial fraction | Rattus norvegicus | 5737 | - |
cytoplasm | chiefly in cytoplasm | Mus musculus | 5737 | - |
cytoplasm | chiefly in cytoplasm | Rattus norvegicus | 5737 | - |
cytoplasm | chiefly in cytoplasm | Oryctolagus cuniculus | 5737 | - |
mitochondrion | mainly in cytoplasm but to a considerable extent also in mitochondrial fraction | Mus musculus | 5739 | - |
mitochondrion | mainly in cytoplasm but to a considerable extent also in mitochondrial fraction | Homo sapiens | 5739 | - |
mitochondrion | mainly in cytoplasm but to a considerable extent also in mitochondrial fraction | Rattus norvegicus | 5739 | - |
particle-bound | - |
Cavia porcellus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
RCH2NH2 + H2O + O2 | Rattus norvegicus | - |
RCHO + NH3 + H2O2 | - |
? | |
RCH2NH2 + H2O + O2 | Cavia porcellus | enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis | RCHO + NH3 + H2O2 | - |
? | |
RCH2NH2 + H2O + O2 | Mus musculus | enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis | RCHO + NH3 + H2O2 | - |
? | |
RCH2NH2 + H2O + O2 | Homo sapiens | enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis | RCHO + NH3 + H2O2 | - |
? | |
RCH2NH2 + H2O + O2 | Sus scrofa | enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis | RCHO + NH3 + H2O2 | - |
? | |
RCH2NH2 + H2O + O2 | Oryctolagus cuniculus | enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis | RCHO + NH3 + H2O2 | - |
? | |
RCH2NH2 + H2O + O2 | Canis lupus familiaris | enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis | RCHO + NH3 + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canis lupus familiaris | - |
- |
- |
Cavia porcellus | - |
- |
- |
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Oryctolagus cuniculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Sus scrofa | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colonic mucosa | - |
Oryctolagus cuniculus | - |
colonic mucosa | - |
Canis lupus familiaris | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.012 | - |
- |
Homo sapiens |
Storage Stability | Organism |
---|---|
-20°C, 24 h, 90% loss of activity | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1,10-diaminodecane + H2O + O2 | - |
Homo sapiens | 10-aminodecanal + NH3 + H2O2 | - |
? | |
1,2-diaminoethane + H2O + O2 | - |
Homo sapiens | 2-aminoethanal + NH3 + H2O2 | - |
? | |
1,3-diaminopropane + H2O + O2 | - |
Homo sapiens | 3-aminopropanal + NH3 + H2O2 | - |
? | |
1,4-diaminobutane + H2O + O2 | - |
Homo sapiens | 4-aminobutanal + NH3 + H2O2 | - |
? | |
1,4-diaminobutane + H2O + O2 | - |
Sus scrofa | 4-aminobutanal + NH3 + H2O2 | - |
? | |
1,5-diaminopentane + H2O + O2 | - |
Homo sapiens | 5-aminopentanal + NH3 + H2O2 | - |
? | |
1,5-diaminopentane + H2O + O2 | - |
Sus scrofa | 5-aminopentanal + NH3 + H2O2 | - |
? | |
1,6-diaminohexane + H2O + O2 | - |
Homo sapiens | 6-aminohexanal + NH3 + H2O2 | - |
? | |
1,7-diaminoheptane + H2O + O2 | - |
Homo sapiens | 7-aminoheptanal + NH3 + H2O2 | - |
? | |
1,8-diaminooctane + H2O + O2 | - |
Homo sapiens | 8-aminooctanal + NH3 + H2O2 | - |
? | |
1,9-diaminononane + H2O + O2 | - |
Homo sapiens | 9-aminononanal + NH3 + H2O2 | - |
? | |
2-methylhistamine + H2O + O2 | - |
Homo sapiens | ? | - |
? | |
5-methylhistamine + H2O + O2 | - |
Homo sapiens | ? | - |
? | |
histamine + H2O + O2 | - |
Homo sapiens | (imidazol-4-yl)acetaldehyde + NH3 + H2O2 | - |
? | |
histamine + H2O + O2 | - |
Sus scrofa | (imidazol-4-yl)acetaldehyde + NH3 + H2O2 | - |
? | |
N(pi)-methylhistamine + H2O + O2 | - |
Homo sapiens | ? | - |
? | |
N(tau)-methylhistamine + H2O + O2 | - |
Homo sapiens | ? | - |
? | |
RCH2NH2 + H2O + O2 | - |
Cavia porcellus | RCHO + NH3 + H2O2 | - |
? | |
RCH2NH2 + H2O + O2 | - |
Mus musculus | RCHO + NH3 + H2O2 | - |
? | |
RCH2NH2 + H2O + O2 | - |
Rattus norvegicus | RCHO + NH3 + H2O2 | - |
? | |
RCH2NH2 + H2O + O2 | - |
Sus scrofa | RCHO + NH3 + H2O2 | - |
? | |
RCH2NH2 + H2O + O2 | - |
Oryctolagus cuniculus | RCHO + NH3 + H2O2 | - |
? | |
RCH2NH2 + H2O + O2 | - |
Canis lupus familiaris | RCHO + NH3 + H2O2 | - |
? | |
RCH2NH2 + H2O + O2 | short-chain aliphatic diamines are deaminated with highest reaction velocity | Homo sapiens | RCHO + NH3 + H2O2 | - |
? | |
RCH2NH2 + H2O + O2 | enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis | Cavia porcellus | RCHO + NH3 + H2O2 | - |
? | |
RCH2NH2 + H2O + O2 | enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis | Mus musculus | RCHO + NH3 + H2O2 | - |
? | |
RCH2NH2 + H2O + O2 | enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis | Homo sapiens | RCHO + NH3 + H2O2 | - |
? | |
RCH2NH2 + H2O + O2 | enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis | Sus scrofa | RCHO + NH3 + H2O2 | - |
? | |
RCH2NH2 + H2O + O2 | enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis | Oryctolagus cuniculus | RCHO + NH3 + H2O2 | - |
? | |
RCH2NH2 + H2O + O2 | enzyme plays a protective role against histamine in diseases such as ischaemic bowel syndrome, mesenteric infarction and ulcerative colitis | Canis lupus familiaris | RCHO + NH3 + H2O2 | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.4 | 6.6 | histamine | Homo sapiens |
6.6 | 7 | putrescine | Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6.2 | 7.8 | pH 6.2 and pH 7.8: about 75% activity, putrescine | Homo sapiens |