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Literature summary for 1.4.3.22 extracted from

  • Sebela, M.; Luhova, L.; Frebort, I.; Faulhammer, H.G.; Hirota, S.; Zajoncova, L.; Stuzka, V.; Pec, P.
    Analysis of the active sites of copper/topa quinone-containing amine oxidases from Lathyrus odoratus and L. sativus seedlings (1998), Phytochem. Anal., 9, 211-222.
No PubMed abstract available
Search for more literature for 1.4.3.22

Inhibitors

Inhibitors Comment Organism Structure
1,4-Diamino-2-butanone
-
 Lathyrus odoratus
1,4-Diamino-2-butanone
-
 Lathyrus sativus
1,5-Diamino-3-pentanone
-
 Lathyrus odoratus
1,5-Diamino-3-pentanone
-
 Lathyrus sativus
2,2'-dipyridiyl
-
 Lathyrus odoratus
2,2'-dipyridyl
-
 Lathyrus odoratus
aminoacetonitrile
-
 Lathyrus odoratus
aminoacetonitrile
-
 Lathyrus sativus
aminoguanidine
-
 Lathyrus odoratus
aminoguanidine
-
 Lathyrus sativus
beta-aminopropionitrile
-
 Lathyrus odoratus
beta-aminopropionitrile
-
 Lathyrus sativus
hydroxylamine
-
 Lathyrus odoratus
hydroxylamine
-
 Lathyrus sativus
Hydroxyquinoline
-
 Lathyrus odoratus
Hydroxyquinoline
-
 Lathyrus sativus
o-phenanthroline
-
 Lathyrus odoratus
o-phenanthroline
-
 Lathyrus sativus
triethyltetramine
-
 Lathyrus odoratus
triethyltetramine
-
 Lathyrus sativus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.09
-
 3-hydroxycadaverine
-
 Lathyrus sativus
0.09
-
 3-hydroxycadaverine
-
 Lathyrus odoratus
0.1
-
 cystamine
-
 Lathyrus sativus
0.1
-
 cystamine
-
 Lathyrus odoratus
0.1
-
 (E)-1,4-diamino-2-butene
-
 Lathyrus sativus
0.1
-
 (E)-1,4-diamino-2-butene
-
 Lathyrus odoratus
0.11
-
 1,6-diaminohexane
-
 Lathyrus sativus
0.11
-
 1,6-diaminohexane
-
 Lathyrus odoratus
0.13
-
 cadaverine
-
 Lathyrus sativus
0.13
-
 cadaverine
-
 Lathyrus odoratus
0.3
-
 putrescine
-
 Lathyrus sativus
0.3
-
 putrescine
-
 Lathyrus odoratus
0.5
-
 agmatine
-
 Lathyrus sativus
0.5
-
 agmatine
-
 Lathyrus odoratus
0.67
-
 2-hydroxyputrescine
-
 Lathyrus sativus
0.67
-
 2-hydroxyputrescine
-
 Lathyrus odoratus
1.45
-
 spermidine
-
 Lathyrus sativus
1.67
-
 spermidine
-
 Lathyrus odoratus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
72000
-
 2 * 72000, SDS-PAGE Lathyrus sativus
72000
-
 2 * 72000, SDS-PAGE Lathyrus odoratus
140000
-
 gel filtration Lathyrus odoratus

Organism

Organism UniProt Comment Textmining
Lathyrus odoratus
-
 sweet pea
-
Lathyrus sativus
-
 grass pea
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein 13% neutral sugars Lathyrus sativus
glycoprotein 10.6% neutral sugars Lathyrus odoratus

Purification (Commentary)

Purification (Comment) Organism
ammonium sulfate, heat denaturation, DEAE-cellulose, hydroxyapatite, Sephacryl S-300 HR Lathyrus sativus
ammonium sulfate, heat denaturation, DEAE-cellulose, hydroxyapatite, Sephacryl S-300 HR Lathyrus odoratus

Source Tissue

Source Tissue Comment Organism Textmining
seedling
-
 Lathyrus sativus
-
seedling
-
 Lathyrus odoratus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
48.61
-
-
 Lathyrus odoratus
64.25
-
-
 Lathyrus sativus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(E)-1,4-diamino-2-butene + H2O + O2
-
 Lathyrus sativus 4-aminobut-2-enal + NH3 + H2O2
-
 r
(E)-1,4-diamino-2-butene + H2O + O2
-
 Lathyrus odoratus 4-aminobut-2-enal + NH3 + H2O2
-
 r
(E,Z)-1,4-diamino-2-butene + H2O + O2
-
 Lathyrus sativus 4-aminobut-2-enal + NH3 + H2O2
-
 ?
(E,Z)-1,4-diamino-2-butene + H2O + O2
-
 Lathyrus odoratus 4-aminobut-2-enal + NH3 + H2O2
-
 ?
1,4-diaminobutane + H2O + O2
-
 Lathyrus sativus 4-aminobutanal + NH3 + H2O2
-
 ?
1,4-diaminobutane + H2O + O2
-
 Lathyrus odoratus 4-aminobutanal + NH3 + H2O2
-
 ?
1,5-diaminopentane + H2O + O2
-
 Lathyrus sativus 5-aminopentanal + NH3 + H2O2
-
 ?
1,5-diaminopentane + H2O + O2
-
 Lathyrus odoratus 5-aminopentanal + NH3 + H2O2
-
 ?
1,6-diaminohexane + H2O + O2
-
 Lathyrus sativus 6-aminohexanal + NH3 + H2O2
-
 ?
1,6-diaminohexane + H2O + O2
-
 Lathyrus odoratus 6-aminohexanal + NH3 + H2O2
-
 ?
2-hydroxyputrescine + H2O + O2
-
 Lathyrus sativus 2-hydroxy-4-aminobutanal + H2O2 + NH3
-
 ?
2-hydroxyputrescine + H2O + O2
-
 Lathyrus odoratus 2-hydroxy-4-aminobutanal + H2O2 + NH3
-
 ?
3-hydroxycadaverine + H2O + O2
-
 Lathyrus sativus 3-hydroxy-4-aminopentanal + H2O2 + NH3
-
 ?
3-hydroxycadaverine + H2O + O2
-
 Lathyrus odoratus 3-hydroxy-4-aminopentanal + H2O2 + NH3
-
 ?
agmatine
-
 Lathyrus sativus ?
-
 ?
agmatine
-
 Lathyrus odoratus ?
-
 ?
cystamine + H2O + O2
-
 Lathyrus sativus 2-mercaptoethanal + H2O2 + NH3
-
 ?
cystamine + H2O + O2
-
 Lathyrus odoratus 2-mercaptoethanal + H2O2 + NH3
-
 ?
p-dimethylaminomethylbenzylamine + H2O + O2
-
 Lathyrus sativus p-dimethylaminomethylbenzaldehyde + NH3 + H2O2
-
 ?
p-dimethylaminomethylbenzylamine + H2O + O2
-
 Lathyrus odoratus p-dimethylaminomethylbenzaldehyde + NH3 + H2O2
-
 ?
RCH2NH2 + H2O + O2 very low activity with: 2-phenylethylamine, tryptamine, histamine, N1-naphthylethylenediamine, dopamine, spermine, benzylamine or homoveratrylamine Lathyrus sativus RCHO + NH3 + H2O2
-
 ?
RCH2NH2 + H2O + O2 very low activity with: 2-phenylethylamine, tryptamine, histamine, N1-naphthylethylenediamine, dopamine, spermine, benzylamine or homoveratrylamine Lathyrus odoratus RCHO + NH3 + H2O2
-
 ?
spermidine + H2O + O2
-
 Lathyrus sativus ?
-
 ?
spermidine + H2O + O2
-
 Lathyrus odoratus ?
-
 ?
tyramine + H2O + O2
-
 Lathyrus sativus 4-hydroxyphenylethanal + NH3 + H2O2
-
 ?
tyramine + H2O + O2
-
 Lathyrus odoratus 4-hydroxyphenylethanal + NH3 + H2O2
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 72000, SDS-PAGE Lathyrus sativus
dimer 2 * 72000, SDS-PAGE Lathyrus odoratus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8 7.8 depending on substrate Lathyrus sativus
6.8 7.8 depending on substrate Lathyrus odoratus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.02
-
 1,4-Diamino-2-butanone
-
 Lathyrus sativus
0.02
-
 1,4-Diamino-2-butanone
-
 Lathyrus odoratus
0.026
-
 1,5-Diamino-3-pentanone
-
 Lathyrus sativus
0.026
-
 1,5-Diamino-3-pentanone
-
 Lathyrus odoratus
0.5
-
 aminoguanidine apparent value Lathyrus sativus
0.5
-
 aminoguanidine apparent value Lathyrus odoratus
0.5
-
 aminoacetonitrile apparent value Lathyrus sativus
0.5
-
 aminoacetonitrile apparent value Lathyrus odoratus
2
-
 triethylentetramine
-
 Lathyrus sativus
2
-
 triethylentetramine
-
 Lathyrus odoratus
6.5
-
 beta-aminopropionitrile
-
 Lathyrus sativus
9
-
 beta-aminopropionitrile
-
 Lathyrus odoratus
14
-
 diethylentriamine
-
 Lathyrus odoratus
16
-
 o-phenanthroline
-
 Lathyrus sativus
16
-
 diethylentriamine
-
 Lathyrus odoratus
18
-
 o-phenanthroline
-
 Lathyrus odoratus
20
-
 Hydroxyquinoline
-
 Lathyrus sativus
35
-
 Hydroxyquinoline
-
 Lathyrus odoratus
50
-
 2,2'-dipyridiyl
-
 Lathyrus odoratus
75
-
 2,2'-dipyridyl
-
 Lathyrus odoratus