Application | Comment | Organism |
---|---|---|
pharmacology | improved food supplements must be developed to help histamine intolerant humans. At least 50 nkat free porcine diamine oxidase are required to convert 75 mg histamine to (imidazol-4-yl)acetaldehyde in an in vitro test system. This results in a reduction of histamine by 90%. The enzyme showes weak stability under simulated intestinal conditions with a half-life period of around 19 min. Therefore, a lot more exogenous diamine oxidase would be required for efficient histamine degradation in the human intestine | Sus scrofa |
General Stability | Organism |
---|---|
the enzyme shows weak stability under simulated intestinal conditions with a half-life period of around 19 min | Sus scrofa |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
histamine | substrate inhibition at 0.5 mM | Sus scrofa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
histamine + H2O + O2 | Sus scrofa | - |
(imidazol-4-yl)acetaldehyde + NH3 + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sus scrofa | Q9TRC7 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Sus scrofa |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Sus scrofa | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
histamine + H2O + O2 | - |
Sus scrofa | (imidazol-4-yl)acetaldehyde + NH3 + H2O2 | - |
? |