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Literature summary for 1.4.3.3 extracted from

  • Setoyama, C.; Nishina,Y.; Tamaoki, H.; Mizutani, H.; Miyahara, I.; Hirotsu, K.; Shiga, K.; Miura, R.
    Effects of hydrogen bond in association with flavin and substrate in flavoenzyme D-amino acid oxidase. The catalytic and structural roles of gly313 and thr317 (2002), J. Biochem., 131, 59-69.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
G313A decreased activities to various D-amino acids Sus scrofa
T317A decreased activity to FAD Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.67
-
D-valine wild-type Sus scrofa
1
-
D-alanine mutant T317A Sus scrofa
1.1
-
D-alanine wild-type Sus scrofa
1.1
-
D-proline wild-type Sus scrofa
1.2
-
D-proline mutant T317A Sus scrofa
1.4
-
D-phenylalanine wild-type Sus scrofa
4.3
-
D-valine mutant T317A Sus scrofa
4.8
-
D-serine wild-type Sus scrofa
9.1
-
D-phenylalanine mutant T317A Sus scrofa
20.8
-
D-serine mutant T317A Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-serine + H2O + O2 Sus scrofa
-
2-oxo-3-hydroxypropionic acid + NH3 + H2O2
-
?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-serine + H2O + O2
-
Sus scrofa 2-oxo-3-hydroxypropionic acid + NH3 + H2O2
-
?
D-serine + H2O + O2
-
Sus scrofa 3-hydroxypyruvate + NH3 + H2O2
-
r

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.9
-
D-valine mutant T317A Sus scrofa
0.92
-
D-alanine mutant T317A Sus scrofa
1.8
-
D-serine mutant T317A Sus scrofa
2.4
-
D-phenylalanine mutant T317A Sus scrofa
2.5
-
D-valine wild-type Sus scrofa
2.7
-
D-serine wild-type Sus scrofa
8.5
-
D-alanine wild-type Sus scrofa
9.7
-
D-proline mutant T317A Sus scrofa
17
-
D-phenylalanine wild-type Sus scrofa
21
-
D-proline wild-type Sus scrofa

Cofactor

Cofactor Comment Organism Structure
FAD flavoprotein Sus scrofa