Literature summary for 1.4.3.3 extracted from

Kawazoe, T.; Tsuge, H.; Imagawa, T.; Aki, K.; Kuramitsu, S.; Fukui, K.
Structural basis of D-DOPA oxidation by D-amino acid oxidase: altersodiumtive pathway for dopamine biosynthesis (2007), Biochem. Biophys. Res. Commun., 355, 385-391.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
substrate-free or in complex with imino-DOPA, hanging drop vapour diffusion method, at 20°C	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
chlorpromazine	-	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
1.1	-	D-tyrosine	in 50 mM sodium diphosphate buffer (pH 8.3) at 25°C	Homo sapiens
1.2	-	D-phenylalanine	in 50 mM sodium diphosphate buffer (pH 8.3) at 25°C	Homo sapiens
1.5	-	D-Dopa	in 50 mM sodium diphosphate buffer (pH 8.3) at 25°C	Homo sapiens
3.9	-	D-serine	in 50 mM sodium diphosphate buffer (pH 8.3) at 25°C	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P14920	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-DOPA + H2O + O2	the maximal velocity for oxidation of D-DOPA is much greater than for D-serine	Homo sapiens	3,4-dihydroxyphenylpyruvic acid + NH3 + H2O2	-	?
D-phenylalanine + H2O + O2	-	Homo sapiens	phenylpyruvate + NH3 + H2O2	-	?
D-serine + H2O + O2	-	Homo sapiens	2-oxo-3-hydroxypropionic acid + NH3 + H2O2	-	?
D-tyrosine + H2O + O2	-	Homo sapiens	4-hydroxyphenylpyruvic acid + NH3 + H2O2	-	?

Synonyms

Synonyms	Comment	Organism
D-amino acid oxidase	-	Homo sapiens
DAO	-	Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
4	-	D-serine	in 50 mM sodium diphosphate buffer (pH 8.3) at 25°C	Homo sapiens
14.83	-	D-tyrosine	in 50 mM sodium diphosphate buffer (pH 8.3) at 25°C	Homo sapiens
15.5	-	D-phenylalanine	in 50 mM sodium diphosphate buffer (pH 8.3) at 25°C	Homo sapiens
21.67	-	D-Dopa	in 50 mM sodium diphosphate buffer (pH 8.3) at 25°C	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
FAD	-	Homo sapiens

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Release 2023.1 (January 2023)