Literature summary for 1.4.3.3 extracted from

Yoshikawa, M.; Shinomiya, T.; Takayasu, N.; Tsukamoto, H.; Kawaguchi, M.; Kobayashi, H.; Oka, T.; Hashimoto, A.
Long-term treatment with morphine increases the D-serine content in the rat brain by regulating the mRNA and protein expressions of serine racemase and D-amino acid oxidase (2008), J. Pharmacol. Sci., 107, 270-276.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	no significant change in the protein expression of DAO is observed after administration of morphine for 30 days in the diencephalon, midbrain, pons medulla, and cerebellum	Rattus norvegicus
morphine	the chronic treatment with morphine produces a slight but significant enhancement in the levels of DAO mRNA in the forebrain regions, the levels increases by 24%-102% in the striatum (87% increase), hippocampus (102%), and cortex (24%)	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	O35078	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain cortex	-	Rattus norvegicus	-
cerebellum	-	Rattus norvegicus	-
corpus striatum	-	Rattus norvegicus	-
diencephalon	-	Rattus norvegicus	-
hippocampus	-	Rattus norvegicus	-
midbrain	-	Rattus norvegicus	-
pons	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-serine + H2O + O2	-	Rattus norvegicus	2-oxo-3-hydroxypropionic acid + NH3 + H2O2	-	?

Synonyms

Synonyms	Comment	Organism
D-amino acid oxidase	-	Rattus norvegicus
DAO	-	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
FAD	-	Rattus norvegicus

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Release 2023.1 (January 2023)