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Literature summary for 1.4.3.3 extracted from
- Commentary: genome-based CNS drug discovery: D-amino acid oxidase (DAAO) as a novel target for antipsychotic medications: progress and challenges (2009), Biochem. Pharmacol., 78, 1360-1365.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| pLG72 | i.e. DAOA or D-amino acid oxidase activator, interacts with and activates the enzyme | Rattus norvegicus | |
| pLG72 | i.e. DAOA or D-amino acid oxidase activator, interacts with and activates the enzyme, genotyping in healthy persons and schizophrenia patients, overview | Homo sapiens |
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | the enzyme is a drug target in schizophrenia | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4H-thieno[3,2-b] pyrrole-5-carboxylic acid | i.e. compound 8, very specific inhibitor of DAAO | Homo sapiens |  |
| 4H-thieno[3,2-b] pyrrole-5-carboxylic acid | i.e. compound 8, very specific inhibitor of DAAO. Compound 8 at 200 mg/kg body weight inhibits rat kidney and cerebellar DAAO by approximately 96% and 80%, respectively. Effects after in vivo application, overview | Rattus norvegicus | |
| 5-methylpyrazole-3-carboxylic acid | i.e. AS057278 | Homo sapiens | |
| 5-methylpyrazole-3-carboxylic acid | i.e. AS057278 | Rattus norvegicus | |
| 6-chlorobenzo[d]isoxazol-3-ol | competitive | Homo sapiens | |
| 6-chlorobenzo[d]isoxazol-3-ol | competitive | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-alanine + H2O + O2 | Homo sapiens | - |
pyruvate + NH3 + H2O2 | - |
? | |
| D-alanine + H2O + O2 | Rattus norvegicus | - |
pyruvate + NH3 + H2O2 | - |
? | |
| D-serine + H2O + O2 | Homo sapiens | - |
2-oxo-3-hydroxypropionate + NH3 + H2O2 | - |
? | |
| D-serine + H2O + O2 | Rattus norvegicus | - |
2-oxo-3-hydroxypropionate + NH3 + H2O2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| brain | - |
Rattus norvegicus | - |
| cerebellum | - |
Rattus norvegicus | - |
| kidney | - |
Homo sapiens | - |
| kidney | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-alanine + H2O + O2 | - |
Homo sapiens | pyruvate + NH3 + H2O2 | - |
? | |
| D-alanine + H2O + O2 | - |
Rattus norvegicus | pyruvate + NH3 + H2O2 | - |
? | |
| D-serine + H2O + O2 | - |
Homo sapiens | 2-oxo-3-hydroxypropionate + NH3 + H2O2 | - |
? | |
| D-serine + H2O + O2 | - |
Rattus norvegicus | 2-oxo-3-hydroxypropionate + NH3 + H2O2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| D-amino acid oxidase | - |
Homo sapiens |
| D-amino acid oxidase | - |
Rattus norvegicus |
| DAAO | - |
Homo sapiens |
| DAAO | - |
Rattus norvegicus |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.000145 | - |
- |
Homo sapiens | 4H-thieno[3,2-b] pyrrole-5-carboxylic acid | |
| 0.000145 | - |
- |
Rattus norvegicus | 4H-thieno[3,2-b] pyrrole-5-carboxylic acid | |
| 0.000188 | - |
- |
Homo sapiens | 6-chlorobenzo[d]isoxazol-3-ol | |
| 0.000188 | - |
- |
Rattus norvegicus | 6-chlorobenzo[d]isoxazol-3-ol | |
| 0.000901 | - |
- |
Homo sapiens | 5-methylpyrazole-3-carboxylic acid | |
| 0.000901 | - |
- |
Rattus norvegicus | 5-methylpyrazole-3-carboxylic acid | |
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