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Literature summary for 1.4.3.3 extracted from

  • Hin, N.; Duvall, B.; Ferraris, D.; Alt, J.; Thomas, A.G.; Rais, R.; Rojas, C.; Wu, Y.; Wozniak, K.M.; Slusher, B.S.; Tsukamoto, T.
    6-Hydroxy-1,2,4-triazine-3,5(2H,4H)-dione derivatives as novel D-amino acid oxidase inhibitors (2015), J. Med. Chem., 58, 7258-7272 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.4.3.3

Inhibitors

Inhibitors Comment Organism Structure
2-(3,3-dimethylbutyl)-6-hydroxy-1,2,4-triazine-3,5(2H,4H)-dione
-
 Homo sapiens
2-benzyl-6-hydroxy-1,2,4-triazine-3,5(2H,4H)-dione
-
 Homo sapiens
2-[2-(1H-benzimidazol-1-yl)ethyl]-6-hydroxy-1,2,4-triazine-3,5(2H,4H)-dione
-
 Homo sapiens
2-{[(3,4-dichlorophenyl)sulfanyl]methyl}-5-hydroxy-4H-pyran-4-one
-
 Homo sapiens
3-(7-hydroxy-2-oxo-4-phenyl-2H-1-benzopyran-6-yl)propanoic acid
-
 Homo sapiens
3-hydroxy-2H-1-benzopyran-2-one
-
 Homo sapiens
3-hydroxyquinolin-2(1H)-one
-
 Homo sapiens
3-methyl-1H-pyrazole-5-carboxylic acid
-
 Homo sapiens
4,6-difluoro-1-hydroxy-1,3-dihydro-2H-benzimidazol-2-one
-
 Homo sapiens
4-[2-(4-chlorophenyl)ethyl]-1H-pyrrole-2-carboxylic acid
-
 Homo sapiens
4H-thieno[3,2-b]pyrrole-5-carboxylic acid
-
 Homo sapiens
6-chloro-1,2-benzoxazol-3-ol
-
 Homo sapiens
6-hydroxy-2-(2-(naphthalen-1-yl)ethyl)-1,2,4-triazine-3,5-(2H,4H)-dione
-
 Homo sapiens
6-hydroxy-2-(2-phenylethyl)-1,2,4-triazine-3,5(2H,4H)-dione
-
 Homo sapiens
6-hydroxy-2-(3-methylbutyl)-1,2,4-triazine-3,5(2H,4H)-dione
-
 Homo sapiens
6-hydroxy-2-(3-phenylpropyl)-1,2,4-triazine-3,5(2H,4H)-dione
-
 Homo sapiens
6-hydroxy-2-methyl-1,2,4-triazine-3,5(2H,4H)-dione
-
 Homo sapiens
6-hydroxy-2-phenyl-1,2,4-triazine-3,5(2H,4H)-dione
-
 Homo sapiens
6-hydroxy-2-[(naphthalen-1-yl)methyl]-1,2,4-triazine-3,5(2H,4H)-dione
-
 Homo sapiens
6-hydroxy-2-[(naphthalen-2-yl)methyl]-1,2,4-triazine-3,5(2H,4H)-dione
-
 Homo sapiens
6-hydroxy-2-[2-(1H-pyrazol-1-yl)ethyl]-1,2,4-triazine-3,5(2H,4H)-dione
-
 Homo sapiens
6-hydroxy-2-[2-(1H-pyrrolo[2,3-b]pyridin-1-yl)ethyl]-1,2,4-triazine-3,5(2H,4H)-dione
-
 Homo sapiens
6-hydroxy-2-[2-(pyridin-2-yl)ethyl]-1,2,4-triazine-3,5(2H,4H)-dione
-
 Homo sapiens
ceftriaxone
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-Ser + H2O + O2 Homo sapiens
-
 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
UNO Q6 column chromatography, and Superdex 200 gel filtration Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-Ser + H2O + O2
-
 Homo sapiens 2-oxo-3-hydroxypropionate + NH3 + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
DAAO
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00005
-
 at pH 8.5 and 25°C Homo sapiens 6-hydroxy-2-[(naphthalen-1-yl)methyl]-1,2,4-triazine-3,5(2H,4H)-dione
0.00007
-
 at pH 8.5 and 25°C Homo sapiens 6-hydroxy-2-(2-phenylethyl)-1,2,4-triazine-3,5(2H,4H)-dione
0.0001
-
 at pH 8.5 and 25°C Homo sapiens 6-hydroxy-2-(2-(naphthalen-1-yl)ethyl)-1,2,4-triazine-3,5-(2H,4H)-dione
0.00022
-
 at pH 8.5 and 25°C Homo sapiens 6-hydroxy-2-[(naphthalen-2-yl)methyl]-1,2,4-triazine-3,5(2H,4H)-dione
0.00026
-
 at pH 8.5 and 25°C Homo sapiens 6-hydroxy-2-(3-methylbutyl)-1,2,4-triazine-3,5(2H,4H)-dione
0.00031
-
 at pH 8.5 and 25°C Homo sapiens 6-hydroxy-2-[2-(1H-pyrrolo[2,3-b]pyridin-1-yl)ethyl]-1,2,4-triazine-3,5(2H,4H)-dione
0.00033
-
 at pH 8.5 and 25°C Homo sapiens 6-hydroxy-2-[2-(1H-pyrazol-1-yl)ethyl]-1,2,4-triazine-3,5(2H,4H)-dione
0.00044
-
 at pH 8.5 and 25°C Homo sapiens 2-[2-(1H-benzimidazol-1-yl)ethyl]-6-hydroxy-1,2,4-triazine-3,5(2H,4H)-dione
0.00076
-
 at pH 8.5 and 25°C Homo sapiens 6-hydroxy-2-[2-(pyridin-2-yl)ethyl]-1,2,4-triazine-3,5(2H,4H)-dione
0.0017
-
 at pH 8.5 and 25°C Homo sapiens 6-hydroxy-2-(3-phenylpropyl)-1,2,4-triazine-3,5(2H,4H)-dione
0.0028
-
 at pH 8.5 and 25°C Homo sapiens 6-hydroxy-2-methyl-1,2,4-triazine-3,5(2H,4H)-dione
0.0051
-
 at pH 8.5 and 25°C Homo sapiens 2-benzyl-6-hydroxy-1,2,4-triazine-3,5(2H,4H)-dione
0.04
-
 at pH 8.5 and 25°C Homo sapiens 2-(3,3-dimethylbutyl)-6-hydroxy-1,2,4-triazine-3,5(2H,4H)-dione
0.1
-
 at pH 8.5 and 25°C Homo sapiens 6-hydroxy-2-phenyl-1,2,4-triazine-3,5(2H,4H)-dione