Cloned (Comment) | Organism |
---|---|
expressed in COS-1 cells | Rattus norvegicus |
expression in Cos-1 cells | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Clorgyline | - |
Rattus norvegicus | |
Deprenyl | - |
Rattus norvegicus | |
Semicarbazide | - |
Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P19643 | - |
- |
Rattus norvegicus | P19643 | nine-week-old male Wistar rats | - |
Rattus norvegicus | P21396 | - |
- |
Rattus norvegicus | P21396 | nine-week-old male Wistar rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.00004 | - |
substrate histamine, at high substrate concentration | Rattus norvegicus |
0.00009 | - |
substrate beta-phenylethylamine, at low substrate concentration | Rattus norvegicus |
0.00011 | - |
substrate tyramine, at low substrate concentration | Rattus norvegicus |
0.00018 | - |
substrate tyramine, at low substrate concentration | Rattus norvegicus |
0.00019 | - |
substrate benzylamine, at low substrate concentration | Rattus norvegicus |
0.00021 | - |
substrate beta-phenylethylamine, at low substrate concentration | Rattus norvegicus |
0.0003 | - |
substrate benzylamine, at low substrate concentration | Rattus norvegicus |
0.00036 | - |
substrate 1-methylhistamine, at high substrate concentration | Rattus norvegicus |
0.00054 | - |
substrate benzylamine, at high substrate concentration | Rattus norvegicus |
0.00054 | - |
substrate histamine, at high substrate concentration | Rattus norvegicus |
0.00092 | - |
substrate beta-phenylethylamine, at high substrate concentration | Rattus norvegicus |
0.00095 | - |
substrate 1-methylhistamine, at high substrate concentration | Rattus norvegicus |
0.00125 | - |
substrate benzylamine, at high substrate concentration | Rattus norvegicus |
0.00155 | - |
substrate tyramine, at high substrate concentration | Rattus norvegicus |
0.00163 | - |
substrate beta-phenylethylamine, at high substrate concentration | Rattus norvegicus |
0.00175 | - |
substrate tyramine, at high substrate concentration | Rattus norvegicus |
0.00316 | - |
substrate serotonin, at low substrate concentration | Rattus norvegicus |
0.0046 | - |
substrate serotonin, at high substrate concentration | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-methylhistamine + H2O + O2 | reaction with MAO-A at 1 mM substrate, no activity at 0.1 mM substrate | Rattus norvegicus | ? | - |
? | |
1-methylhistamine + H2O + O2 | reaction with MAO-B at 1 mM substrate, no activity at 0.1 mM substrate | Rattus norvegicus | 1-methyl-1H-imidazol-4-ylacetaldehyde + NH3 + H2O2 | - |
? | |
1-methylhistamine + O2 + H2O | - |
Rattus norvegicus | 1-methyl-1H-imidazol-4-ylacetaldehyde + NH3 + H2O2 | - |
? | |
2-phenylethylamine + H2O + O2 | reaction with MAO-A | Rattus norvegicus | 2-phenylethanal + NH3 + H2O2 | - |
? | |
2-phenylethylamine + H2O + O2 | reaction with MAO-B | Rattus norvegicus | 2-phenylethanal + NH3 + H2O2 | - |
? | |
benzylamine + H2O + O2 | reaction with MAO-A | Rattus norvegicus | benzaldehyde + NH3 + H2O2 | - |
? | |
benzylamine + H2O + O2 | reaction with MAO-B | Rattus norvegicus | benzaldehyde + NH3 + H2O2 | - |
? | |
benzylamine + O2 + H2O | - |
Rattus norvegicus | benzaldehyde + NH3 + H2O2 | - |
? | |
beta-phenylethylamine + O2 + H2O | - |
Rattus norvegicus | beta-phenylethanal + NH3 + H2O2 | - |
? | |
histamine + H2O + O2 | reaction with MAO-B at 1 mM substrate, no activity at 0.1 mM substrate | Rattus norvegicus | 1H-imidazol-4-ylacetaldehyde + NH3 + H2O2 | - |
? | |
histamine + H2O + O2 | reaction with MAO-A at 1 mM substrate, no activity at 0.1 mM substrate | Rattus norvegicus | ? | - |
? | |
histamine + O2 + H2O | - |
Rattus norvegicus | 1H-imidazol-4-ylacetaldehyde + NH3 + H2O2 | - |
? | |
additional information | MAOB shows no activity with serotonin | Rattus norvegicus | ? | - |
? | |
serotonin + H2O + O2 | reaction with MAO-A | Rattus norvegicus | (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2 | - |
? | |
serotonin + O2 + H2O | 5-hydroxytryptamine, MAO-A | Rattus norvegicus | (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2 | - |
? | |
tyramine + H2O + O2 | reaction with MAO-A | Rattus norvegicus | (4-hydroxyphenyl)acetaldehyde + NH3 + H2O2 | - |
? | |
tyramine + H2O + O2 | reaction with MAO-B | Rattus norvegicus | (4-hydroxyphenyl)acetaldehyde + NH3 + H2O2 | - |
? | |
tyramine + O2 + H2O | - |
Rattus norvegicus | (4-hydroxyphenyl)acetaldehyde + NH3 + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MAO-A | - |
Rattus norvegicus |
MAO-B | - |
Rattus norvegicus |
monoamine oxidase A | - |
Rattus norvegicus |
monoamine oxidase B | - |
Rattus norvegicus |