Any feedback?
Literature summary for 1.4.3.4 extracted from
- Substrate selectivity of monoamine oxidase A, monoamine oxidase B, diamine oxidase, and semicarbazide-sensitive amine oxidase in COS-1 expression systems (2006), Biol. Pharm. Bull., 29, 2362-2366.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in COS-1 cells | Rattus norvegicus |
| expression in Cos-1 cells | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Clorgyline | - |
Rattus norvegicus |  |
| Deprenyl | - |
Rattus norvegicus | |
| Semicarbazide | - |
Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | P19643 | - |
- |
| Rattus norvegicus | P19643 | nine-week-old male Wistar rats | - |
| Rattus norvegicus | P21396 | - |
- |
| Rattus norvegicus | P21396 | nine-week-old male Wistar rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.00004 | - |
substrate histamine, at high substrate concentration | Rattus norvegicus |
| 0.00009 | - |
substrate beta-phenylethylamine, at low substrate concentration | Rattus norvegicus |
| 0.00011 | - |
substrate tyramine, at low substrate concentration | Rattus norvegicus |
| 0.00018 | - |
substrate tyramine, at low substrate concentration | Rattus norvegicus |
| 0.00019 | - |
substrate benzylamine, at low substrate concentration | Rattus norvegicus |
| 0.00021 | - |
substrate beta-phenylethylamine, at low substrate concentration | Rattus norvegicus |
| 0.0003 | - |
substrate benzylamine, at low substrate concentration | Rattus norvegicus |
| 0.00036 | - |
substrate 1-methylhistamine, at high substrate concentration | Rattus norvegicus |
| 0.00054 | - |
substrate benzylamine, at high substrate concentration | Rattus norvegicus |
| 0.00054 | - |
substrate histamine, at high substrate concentration | Rattus norvegicus |
| 0.00092 | - |
substrate beta-phenylethylamine, at high substrate concentration | Rattus norvegicus |
| 0.00095 | - |
substrate 1-methylhistamine, at high substrate concentration | Rattus norvegicus |
| 0.00125 | - |
substrate benzylamine, at high substrate concentration | Rattus norvegicus |
| 0.00155 | - |
substrate tyramine, at high substrate concentration | Rattus norvegicus |
| 0.00163 | - |
substrate beta-phenylethylamine, at high substrate concentration | Rattus norvegicus |
| 0.00175 | - |
substrate tyramine, at high substrate concentration | Rattus norvegicus |
| 0.00316 | - |
substrate serotonin, at low substrate concentration | Rattus norvegicus |
| 0.0046 | - |
substrate serotonin, at high substrate concentration | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-methylhistamine + H2O + O2 | reaction with MAO-A at 1 mM substrate, no activity at 0.1 mM substrate | Rattus norvegicus | ? | - |
? | |
| 1-methylhistamine + H2O + O2 | reaction with MAO-B at 1 mM substrate, no activity at 0.1 mM substrate | Rattus norvegicus | 1-methyl-1H-imidazol-4-ylacetaldehyde + NH3 + H2O2 | - |
? | |
| 1-methylhistamine + O2 + H2O | - |
Rattus norvegicus | 1-methyl-1H-imidazol-4-ylacetaldehyde + NH3 + H2O2 | - |
? | |
| 2-phenylethylamine + H2O + O2 | reaction with MAO-A | Rattus norvegicus | 2-phenylethanal + NH3 + H2O2 | - |
? | |
| 2-phenylethylamine + H2O + O2 | reaction with MAO-B | Rattus norvegicus | 2-phenylethanal + NH3 + H2O2 | - |
? | |
| benzylamine + H2O + O2 | reaction with MAO-A | Rattus norvegicus | benzaldehyde + NH3 + H2O2 | - |
? | |
| benzylamine + H2O + O2 | reaction with MAO-B | Rattus norvegicus | benzaldehyde + NH3 + H2O2 | - |
? | |
| benzylamine + O2 + H2O | - |
Rattus norvegicus | benzaldehyde + NH3 + H2O2 | - |
? | |
| beta-phenylethylamine + O2 + H2O | - |
Rattus norvegicus | beta-phenylethanal + NH3 + H2O2 | - |
? | |
| histamine + H2O + O2 | reaction with MAO-B at 1 mM substrate, no activity at 0.1 mM substrate | Rattus norvegicus | 1H-imidazol-4-ylacetaldehyde + NH3 + H2O2 | - |
? | |
| histamine + H2O + O2 | reaction with MAO-A at 1 mM substrate, no activity at 0.1 mM substrate | Rattus norvegicus | ? | - |
? | |
| histamine + O2 + H2O | - |
Rattus norvegicus | 1H-imidazol-4-ylacetaldehyde + NH3 + H2O2 | - |
? | |
| additional information | MAOB shows no activity with serotonin | Rattus norvegicus | ? | - |
? | |
| serotonin + H2O + O2 | reaction with MAO-A | Rattus norvegicus | (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2 | - |
? | |
| serotonin + O2 + H2O | 5-hydroxytryptamine, MAO-A | Rattus norvegicus | (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2 | - |
? | |
| tyramine + H2O + O2 | reaction with MAO-A | Rattus norvegicus | (4-hydroxyphenyl)acetaldehyde + NH3 + H2O2 | - |
? | |
| tyramine + H2O + O2 | reaction with MAO-B | Rattus norvegicus | (4-hydroxyphenyl)acetaldehyde + NH3 + H2O2 | - |
? | |
| tyramine + O2 + H2O | - |
Rattus norvegicus | (4-hydroxyphenyl)acetaldehyde + NH3 + H2O2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MAO-A | - |
Rattus norvegicus |
| MAO-B | - |
Rattus norvegicus |
| monoamine oxidase A | - |
Rattus norvegicus |
| monoamine oxidase B | - |
Rattus norvegicus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
