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Literature summary for 1.4.3.4 extracted from

  • Bissel, P.; Khalil, A.; Rimoldi, J.M.; Igarashi, K.; Edmondson, D.; Miller, A.; Castagnoli, N.
    Stereochemical studies on the novel monoamine oxidase B substrates (1R,6S)- and (1S,6R)-3-methyl-6-phenyl-3-aza-bicyclo[4.1.0]heptane (2008), Bioorg. Med. Chem., 16, 3557-3564.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.221
-
(1R,6S)-3-methyl-6-phenyl-3-aza-bicyclo[4.1.0]heptane pH 7.0, 37°C Homo sapiens
0.753
-
(1S,6R)-3-methyl-6-phenyl-3-aza-bicyclo[4.1.0]heptane pH 7.0, 37°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P27338
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(1R,6S)-3-methyl-6-phenyl-3-aza-bicyclo[4.1.0]heptane + H2O + O2 MAO-B catalyzed ring alpha-carbon oxidation of 3-methyl-6-phenyl-3-aza-bicyclo[4.1.0]heptane is enantioselective with an almost 5fold preference for the (1R,6S) enantiomer based on Vmax/Km values Homo sapiens ?
-
?
(1S,6R)-3-methyl-6-phenyl-3-azabicyclo[4.1.0]heptane + H2O + O2 MAO-B catalyzed ring alpha-carbon oxidation of 3-methyl-6-phenyl-3-aza-bicyclo[4.1.0]heptane is enantioselective with an almost 5fold preference for the (1R,6S) enantiomer based on Vmax/Km values Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
MAO-B
-
Homo sapiens
monoamine oxidase-B
-
Homo sapiens