Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(1E,2E)-3-(furan-2-yl)-N-(prop-2-yn-1-yl)prop-2-en-1-imine | - |
Homo sapiens | |
(E)-1-(2,3-dimethoxy-6-methylphenyl)-N-(prop-2-yn-1-yl)methanimine | - |
Homo sapiens | |
(E)-1-(2,3-dimethylphenyl)-N-(prop-2-yn-1-yl)methanimine | - |
Homo sapiens | |
(E)-1-(2-chloro-4-fluorophenyl)-N-(prop-2-yn-1-yl)methanimine | - |
Homo sapiens | |
(E)-1-(2-chloroquinolin-3-yl)-N-(prop-2-yn-1-yl)methanimine | - |
Homo sapiens | |
(E)-1-(4-methoxy-2,3-dimethylphenyl)-N-(prop-2-yn-1-yl)methanimine | - |
Homo sapiens | |
(E)-1-(4-phenoxyphenyl)-N-(prop-2-yn-1-yl)methanimine | - |
Homo sapiens | |
(E)-1-(5-bromo-2-methoxyphenyl)-N-(prop-2-yn-1-yl)methanimine | - |
Homo sapiens | |
(E)-1-phenyl-N-(prop-2-yn-1-yl)methanimine | - |
Homo sapiens | |
(E)-N-(prop-2-yn-1-yl)-1-(3,4,5-trimethoxyphenyl)methanimine | - |
Homo sapiens | |
(E)-N-(prop-2-yn-1-yl)-1-[4-(pyridin-2-yl)phenyl]methanimine | - |
Homo sapiens | |
2-(methyl[4-[(E)-(prop-2-yn-1-ylimino)methyl]phenyl]amino)ethanol | - |
Homo sapiens | |
2-chloro-5-[(E)-(prop-2-yn-1-ylimino)methyl]phenol | - |
Homo sapiens | |
2-ethoxy-6-[(E)-(prop-2-yn-1-ylimino)methyl]phenol | - |
Homo sapiens | |
2-[(E)-(prop-2-yn-1-ylimino)methyl]benzene-1,4-diol | - |
Homo sapiens | |
3,4-dimethoxy-(benzylidene)-prop-2-ynylamine | - |
Homo sapiens | |
3,5-dimethyl-(1H-pyrrol-2-ylmethylene)-prop-2-ynyl-amine | - |
Homo sapiens | |
3-[(E)-(prop-2-yn-1-ylimino)methyl]naphthalen-2-ol | - |
Homo sapiens | |
5-chloro-2-[(E)-(prop-2-yn-1-ylimino)methyl]phenol | - |
Homo sapiens | |
5-chloro-2-[(prop-2-yn-1-ylamino)methyl]phenol | - |
Homo sapiens | |
benzhydrylidene-prop-2-ynyl-amine | - |
Homo sapiens | |
methyl 4'-[(E)-(prop-2-yn-1-ylimino)methyl]biphenyl-4-carboxylate | - |
Homo sapiens | |
additional information | development and synthesis of benzylidene-prop-2-ynyl-amines analogues as monoamine oxidase inhibitors, ligand docking and molecular modelling, overview. In the active center, Ile199 is the gate residue, and two hydrophobic areas of the enzyme are implicated in the most stable binding mode. Hydrophobic pocket is delimited by Ile198, Ile199, Gln206, Phe343, and aromatic cage contains FAD, Tyr398 and Tyr435 | Homo sapiens | |
N-benzyl-N-methylprop-2-yn-1-amine | i.e. pargyline | Homo sapiens | |
N-benzylprop-2-yn-1-amine | - |
Homo sapiens | |
N-[3-(2,4-dichlorophenoxy)propyl]-N-methyl-prop-2-yn-1-amine | i.e. clorgiline | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
MAO-A | - |
Homo sapiens |
MAO-B | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000022 | - |
MAO A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | N-[3-(2,4-dichlorophenoxy)propyl]-N-methyl-prop-2-yn-1-amine | |
0.000014 | - |
MAO A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 3,4-dimethoxy-(benzylidene)-prop-2-ynylamine | |
0.000032 | - |
MAO B, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | benzhydrylidene-prop-2-ynyl-amine | |
0.000038 | - |
MAO B, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | N-benzyl-N-methylprop-2-yn-1-amine | |
0.000048 | - |
MAO A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 3,5-dimethyl-(1H-pyrrol-2-ylmethylene)-prop-2-ynyl-amine | |
0.000051 | - |
MAO B, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 3,4-dimethoxy-(benzylidene)-prop-2-ynylamine | |
0.0001 | - |
MAO A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (E)-1-(4-phenoxyphenyl)-N-(prop-2-yn-1-yl)methanimine | |
0.00011 | - |
MAO A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | benzhydrylidene-prop-2-ynyl-amine | |
0.00014 | - |
MAO A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-[(E)-(prop-2-yn-1-ylimino)methyl]benzene-1,4-diol | |
0.00016 | - |
MAO A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (E)-N-(prop-2-yn-1-yl)-1-[4-(pyridin-2-yl)phenyl]methanimine | |
0.00018 | - |
MAO A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (E)-1-phenyl-N-(prop-2-yn-1-yl)methanimine | |
0.00019 | - |
MAO A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (E)-1-(4-methoxy-2,3-dimethylphenyl)-N-(prop-2-yn-1-yl)methanimine | |
0.00019 | - |
MAO B, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (E)-1-(2,3-dimethylphenyl)-N-(prop-2-yn-1-yl)methanimine | |
0.00026 | - |
MAO A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 3-[(E)-(prop-2-yn-1-ylimino)methyl]naphthalen-2-ol | |
0.00048 | - |
MAO B, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (E)-1-(4-phenoxyphenyl)-N-(prop-2-yn-1-yl)methanimine | |
0.00055 | - |
MAO A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (E)-N-(prop-2-yn-1-yl)-1-(3,4,5-trimethoxyphenyl)methanimine | |
0.00063 | - |
MAO B, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (E)-1-(4-methoxy-2,3-dimethylphenyl)-N-(prop-2-yn-1-yl)methanimine | |
0.00065 | - |
MAO A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (E)-1-(2,3-dimethylphenyl)-N-(prop-2-yn-1-yl)methanimine | |
0.00084 | - |
MAO B, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 3-[(E)-(prop-2-yn-1-ylimino)methyl]naphthalen-2-ol | |
0.00088 | - |
MAO A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-ethoxy-6-[(E)-(prop-2-yn-1-ylimino)methyl]phenol | |
0.00089 | - |
MAO A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 5-chloro-2-[(prop-2-yn-1-ylamino)methyl]phenol | |
0.0009 | - |
MAO A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 5-chloro-2-[(E)-(prop-2-yn-1-ylimino)methyl]phenol | |
0.00104 | - |
MAO A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-chloro-5-[(E)-(prop-2-yn-1-ylimino)methyl]phenol | |
0.00114 | - |
MAO B, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (E)-N-(prop-2-yn-1-yl)-1-[4-(pyridin-2-yl)phenyl]methanimine | |
0.00137 | - |
MAO A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (E)-1-(2-chloro-4-fluorophenyl)-N-(prop-2-yn-1-yl)methanimine | |
0.00137 | - |
MAO B, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-ethoxy-6-[(E)-(prop-2-yn-1-ylimino)methyl]phenol | |
0.00161 | - |
MAO B, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (E)-1-(2-chloro-4-fluorophenyl)-N-(prop-2-yn-1-yl)methanimine | |
0.00171 | - |
MAO A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (E)-1-(5-bromo-2-methoxyphenyl)-N-(prop-2-yn-1-yl)methanimine | |
0.00219 | - |
MAO B, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (E)-1-(5-bromo-2-methoxyphenyl)-N-(prop-2-yn-1-yl)methanimine | |
0.00234 | - |
MAO B, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | methyl 4'-[(E)-(prop-2-yn-1-ylimino)methyl]biphenyl-4-carboxylate | |
0.00234 | - |
MAO B, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 5-chloro-2-[(prop-2-yn-1-ylamino)methyl]phenol | |
0.00243 | - |
MAO B, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-[(E)-(prop-2-yn-1-ylimino)methyl]benzene-1,4-diol | |
0.00283 | - |
MAO B, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 3,5-dimethyl-(1H-pyrrol-2-ylmethylene)-prop-2-ynyl-amine | |
0.00298 | - |
MAO A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (E)-1-(2-chloroquinolin-3-yl)-N-(prop-2-yn-1-yl)methanimine | |
0.00348 | - |
MAO B, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (E)-1-(2,3-dimethoxy-6-methylphenyl)-N-(prop-2-yn-1-yl)methanimine | |
0.00388 | - |
MAO A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-(methyl[4-[(E)-(prop-2-yn-1-ylimino)methyl]phenyl]amino)ethanol | |
0.00401 | - |
MAO A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | N-benzylprop-2-yn-1-amine | |
0.00439 | - |
MAO B, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (E)-N-(prop-2-yn-1-yl)-1-(3,4,5-trimethoxyphenyl)methanimine | |
0.00527 | - |
MAO A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (E)-1-(2,3-dimethoxy-6-methylphenyl)-N-(prop-2-yn-1-yl)methanimine | |
0.00536 | - |
MAO A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | methyl 4'-[(E)-(prop-2-yn-1-ylimino)methyl]biphenyl-4-carboxylate | |
0.00717 | - |
MAO B, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (E)-1-phenyl-N-(prop-2-yn-1-yl)methanimine | |
0.00828 | - |
MAO B, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (E)-1-(2-chloroquinolin-3-yl)-N-(prop-2-yn-1-yl)methanimine | |
0.00991 | - |
MAO B, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-(methyl[4-[(E)-(prop-2-yn-1-ylimino)methyl]phenyl]amino)ethanol | |
0.01062 | - |
MAO B, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-chloro-5-[(E)-(prop-2-yn-1-ylimino)methyl]phenol | |
0.01665 | - |
MAO A, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (1E,2E)-3-(furan-2-yl)-N-(prop-2-yn-1-yl)prop-2-en-1-imine | |
0.0365 | - |
MAO B, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 5-chloro-2-[(E)-(prop-2-yn-1-ylimino)methyl]phenol | |
0.1088 | - |
MAO B, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | N-benzylprop-2-yn-1-amine | |
0.1374 | - |
MAO B, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (1E,2E)-3-(furan-2-yl)-N-(prop-2-yn-1-yl)prop-2-en-1-imine |