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Literature summary for 1.4.3.4 extracted from

  • Alcaro, S.; Gaspar, A.; Ortuso, F.; Milhazes, N.; Orallo, F.; Uriarte, E.; Yanez, M.; Borges, F.
    Chromone-2- and -3-carboxylic acids inhibit differently monoamine oxidases A and B (2010), Bioorg. Med. Chem. Lett., 20, 2709-2712.
    View publication on PubMed
Search for more literature for 1.4.3.4

Inhibitors

Inhibitors Comment Organism Structure
4-oxo-4H-chromene-3-carboxylic acid specific for MAO-B Homo sapiens
Clorgyline inhibits both MAO-A and MAO-B Homo sapiens
Iproniazide inhibits both MAO-A and MAO-B Homo sapiens
moclobemide specific for MAO-A Homo sapiens
additional information evaluation of chromone carboxylic acids as enzyme inhibitors, only chromone-3-carboxylic acid is a potent MAO-B inhibitor, with a high degree of selectivity for MAO-B compared to MAO-A, no inhibition by 4-oxo-4H-chromene-2-carboxylic acid at 0.1 mM, molecular docking, overview Homo sapiens
R-(-)-deprenyl inhibits both MAO-A and MAO-B Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-phenylethylamine + H2O + O2 Homo sapiens
-
 ?
-
 ?
benzylamine + H2O + O2 Homo sapiens
-
 benzaldehyde + NH3 + H2O2
-
 ?
dopamine + H2O + O2 Homo sapiens
-
 ?
-
 ?
norepinephrine + H2O + O2 Homo sapiens
-
 ?
-
 ?
serotonin + H2O + O2 Homo sapiens substrate of MAO-A (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
 ?
tyramine + H2O + O2 Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-phenylethylamine + H2O + O2
-
 Homo sapiens ?
-
 ?
benzylamine + H2O + O2
-
 Homo sapiens benzaldehyde + NH3 + H2O2
-
 ?
dopamine + H2O + O2
-
 Homo sapiens ?
-
 ?
norepinephrine + H2O + O2
-
 Homo sapiens ?
-
 ?
serotonin + H2O + O2 substrate of MAO-A Homo sapiens (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
 ?
tyramine + H2O + O2
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
MAO-A
-
 Homo sapiens
MAO-B
-
 Homo sapiens
monoamine oxidases A
-
 Homo sapiens
monoamine oxidases B
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000052
-
 MAO-A, pH not specified in the publication, temperature not specified in the publication Homo sapiens Clorgyline
0.000017
-
 MAO-B, pH not specified in the publication, temperature not specified in the publication Homo sapiens R-(-)-deprenyl
0.00656
-
 MAO-A, pH not specified in the publication, temperature not specified in the publication Homo sapiens Iproniazide
0.00754
-
 MAO-B, pH not specified in the publication, temperature not specified in the publication Homo sapiens Iproniazide
0.0634
-
 MAO-B, pH not specified in the publication, temperature not specified in the publication Homo sapiens Clorgyline
0.0687
-
 MAO-A, pH not specified in the publication, temperature not specified in the publication Homo sapiens R-(-)-deprenyl
0.3614
-
 MAO-A, pH not specified in the publication, temperature not specified in the publication Homo sapiens moclobemide