Literature summary for 1.4.3.4 extracted from

Herraiz, T.; Gonzalez, D.; Ancin-Azpilicueta, C.; Aran, V.J.; Guillen, H.
beta-Carboline alkaloids in Peganum harmala and inhibition of human monoamine oxidase (MAO) (2010), Food Chem. Toxicol., 48, 839-845.

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Inhibitors

Inhibitors	Comment	Organism	Structure
Harmaline	identification by HPLC-ESI-mass spectrometry. Potent reversible and strong inhibition of MAO-A, poor inhibition of MAO-B, from seeds	Homo sapiens
harmalol	identification by HPLC-ESI-mass spectrometry	Homo sapiens
harmine	identification by HPLC-ESI-mass spectrometry. Potent reversible and strong inhibition of MAO-A, poor inhibition of MAO-B, from seeds	Homo sapiens
harmol	identification by HPLC-ESI-mass spectrometry	Homo sapiens
additional information	enzyme inhibition by beta-carboline alkaloids from seeds and roots of Peganum harmala, low levels in stems and leaves, and absence in flowers, overview. Seed extracts are potent reversible and competitive inhibitors of human MAO-A with an IC50 of 0.027 mg/L whereas root extracts strongly inhibit MAO-A with an IC50 of 0.159 mg/L. In contrast, they are poor inhibitors of MAO-B. Inhibition of MAO-A by seed extracts is quantitatively attributed to harmaline and harmine whereas inhibition by root extracts came from harmine with no additional interferences	Homo sapiens
tetrahydroharmine	identification by HPLC-ESI-mass spectrometry	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
kynuramine + O2	-	Homo sapiens	4-hydroxyquinoline + NH3 + H2O2	-	?

Synonyms

Synonyms	Comment	Organism
MAO	-	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	assay at	Homo sapiens

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Release 2023.1 (January 2023)