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Literature summary for 1.4.3.4 extracted from

  • Sun, Y.; Chen, J.; Chen, X.; Huang, L.; Li, X.
    Inhibition of cholinesterase and monoamine oxidase-B activity by tacrine-homoisoflavonoid hybrids (2013), Bioorg. Med. Chem., 21, 7406-7417 .
    View publication on PubMed
Search for more literature for 1.4.3.4

Inhibitors

Inhibitors Comment Organism Structure
(3E)-7-hydroxy-3-[(4-methoxyphenyl)methylidene]-2,3-dihydro-4H-1-benzopyran-4-one
-
 Homo sapiens
(E)-3-(2-methoxybenzylidene)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
-
 Homo sapiens
(E)-3-(3,4-dimethoxybenzylidene)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
-
 Homo sapiens
(E)-3-(3-methoxybenzylidene)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
-
 Homo sapiens
(E)-3-(4-(diethylamino)benzylidene)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
-
 Homo sapiens
(E)-3-(4-(dimethylamino)benzylidene)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
-
 Homo sapiens
(E)-3-(4-chlorobenzylidene)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
-
 Homo sapiens
(E)-3-(4-fluorobenzylidene)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
-
 Homo sapiens
(E)-3-(4-methoxybenzylidene)-7-(10-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
-
 Homo sapiens
(E)-3-(4-methoxybenzylidene)-7-(5-(1,2,3,4-tetrahydroacridin-9-ylamino)pentyloxy)chroman-4-one
-
 Homo sapiens
(E)-3-(4-methoxybenzylidene)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
-
 Homo sapiens
(E)-3-(4-methoxybenzylidene)-7-(8-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
-
 Homo sapiens
(E)-3-(4-methoxybenzylidene)-7-(9-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
-
 Homo sapiens
(E)-3-(4-methylbenzylidene)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
-
 Homo sapiens
(E)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)-3-(3,4,5-trimethoxybenzylidene)chroman-4-one
-
 Homo sapiens
(E)-7-(6-(6-chloro-1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)-3-(4-methoxybenzylidene)chroman-4-one
-
 Homo sapiens
(E)-7-(8-(6-chloro-1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)3-(4-methoxybenzylidene)chroman-4-one
-
 Homo sapiens
1,2,3,4-tetrahydroacridin-9-amine
-
 Homo sapiens
3-(4-methoxybenzyl)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
-
 Homo sapiens
Clorgyline isoform MAO-A, 4.1% inhibition at 0.1 mM Homo sapiens
ladostigil
-
 Homo sapiens
Pargyline
-
 Homo sapiens
rasagiline
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P27338
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-tyramine + H2O + O2
-
 Homo sapiens (4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
MAO-A
-
 Homo sapiens
MAO-B
-
 Homo sapiens
monoamine oxidase-A
-
 Homo sapiens
monoamine oxidase-B
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000401
-
 (E)-3-(4-methoxybenzylidene)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one isoform MAO-B, at pH 8.0 and 37°C Homo sapiens
0.000437
-
 (E)-3-(4-methoxybenzylidene)-7-(9-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one isoform MAO-B, at pH 8.0 and 37°C Homo sapiens
0.000518
-
 (E)-3-(4-methoxybenzylidene)-7-(8-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one isoform MAO-B, at pH 8.0 and 37°C Homo sapiens
0.00103
-
 (E)-3-(4-(dimethylamino)benzylidene)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one isoform MAO-B, at pH 8.0 and 37°C Homo sapiens
0.00106
-
 (3E)-7-hydroxy-3-[(4-methoxyphenyl)methylidene]-2,3-dihydro-4H-1-benzopyran-4-one isoform MAO-B, at pH 8.0 and 37°C Homo sapiens
0.00109
-
 (E)-3-(4-fluorobenzylidene)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one isoform MAO-B, at pH 8.0 and 37°C Homo sapiens
0.00111
-
 3-(4-methoxybenzyl)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one isoform MAO-B, at pH 8.0 and 37°C Homo sapiens
0.00116
-
 (E)-3-(4-methoxybenzylidene)-7-(5-(1,2,3,4-tetrahydroacridin-9-ylamino)pentyloxy)chroman-4-one isoform MAO-B, at pH 8.0 and 37°C Homo sapiens
0.00124
-
 (E)-3-(4-methylbenzylidene)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one isoform MAO-B, at pH 8.0 and 37°C Homo sapiens
0.00136
-
 (E)-7-(6-(6-chloro-1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)-3-(4-methoxybenzylidene)chroman-4-one isoform MAO-B, at pH 8.0 and 37°C Homo sapiens
0.00156
-
 (E)-7-(8-(6-chloro-1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)3-(4-methoxybenzylidene)chroman-4-one isoform MAO-B, at pH 8.0 and 37°C Homo sapiens
0.00179
-
 (E)-3-(2-methoxybenzylidene)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one isoform MAO-B, at pH 8.0 and 37°C Homo sapiens
0.0022
-
 (E)-3-(3-methoxybenzylidene)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one isoform MAO-B, at pH 8.0 and 37°C Homo sapiens
0.00343
-
 (E)-3-(4-methoxybenzylidene)-7-(10-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one isoform MAO-B, at pH 8.0 and 37°C Homo sapiens
0.0154
-
 (E)-3-(4-chlorobenzylidene)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one isoform MAO-B, at pH 8.0 and 37°C Homo sapiens
0.01973
-
 (E)-3-(3,4-dimethoxybenzylidene)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one isoform MAO-B, at pH 8.0 and 37°C Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000188
-
 isoform MAO-B, at pH 8.0 and 37°C Homo sapiens Pargyline
0.0371
-
 isoform MAO-B, at pH 8.0 and 37°C Homo sapiens ladostigil