Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-phenyl-4-(phenylseleno)isoquinoline | reversibly inhibits isoform MAO-B activity | Rattus norvegicus | |
3-phenyl-4-(phenylthio)isoquinoline | - |
Rattus norvegicus | |
4-(4-fluorophenylseleno)-3-phenylisoquinoline | - |
Rattus norvegicus | |
additional information | 3-phenyl-4-(phenyltelluro) isoquinoline does not inhibit 50% of the isoform MAO-B activity up to concentration of 0.1 mM | Rattus norvegicus | |
rasagiline | specific MAO-B inhibitor | Rattus norvegicus | |
selegiline | specific MAO-B inhibitor | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Rattus norvegicus | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P19643 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
kynuramine + O2 | - |
Rattus norvegicus | 4-hydroxyquinoline + NH3 + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MAO-B | isoform | Rattus norvegicus |
monoamine oxidase B | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.03645 | - |
isoform MAO-B, at pH 7.4 and 37°C | Rattus norvegicus | 3-phenyl-4-(phenylseleno)isoquinoline | |
0.07586 | - |
isoform MAO-B, at pH 7.4 and 37°C | Rattus norvegicus | 3-phenyl-4-(phenylthio)isoquinoline | |
0.08241 | - |
isoform MAO-B, at pH 7.4 and 37°C | Rattus norvegicus | 4-(4-fluorophenylseleno)-3-phenylisoquinoline |