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Literature summary for 1.4.99.5 extracted from

  • Blumer, C.; Haas, D.
    Iron regulation of the hcnABC genes encoding hydrogen cyanide synthase depends on the anaerobic regulator ANR rather than on the global activator GacA in Pseudomonas fluorescens CHA0 (2000), Microbiology, 146, 2417-2424.
No PubMed abstract available

Activating Compound

Activating Compound Comment Organism Structure
additional information ANR, anaerobic regulator required for maximal expression of the HCN biosynthetic genes Pseudomonas fluorescens

Cloned(Commentary)

Cloned (Comment) Organism
hcnABC gene cluster encoding hydrogen cyanide synthase, heterologously expressed in Escherichia coli Pseudomonas fluorescens

Inhibitors

Inhibitors Comment Organism Structure
O2
-
Pseudomonas aeruginosa
O2 very sensitive to molecular oxygen, becomes rapidly inactivated in presence Pseudomonas fluorescens

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ iron regulation of the hcnABC genes encoding hydrogen cyanide synthase, iron limitation has negative effect on hcn expression Pseudomonas fluorescens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glycine + O2 Pseudomonas fluorescens
-
HCN + CO2 + 2 H2O
-
?
glycine + O2 Pseudomonas aeruginosa
-
HCN + CO2 + 2 H2O
-
?
glycine + O2 Chromobacterium violaceum
-
HCN + CO2 + 2 H2O
-
?
glycine + O2 Pseudomonas aeruginosa PAO1A4
-
HCN + CO2 + 2 H2O
-
?
glycine + O2 Pseudomonas fluorescens CHA0
-
HCN + CO2 + 2 H2O
-
?

Organism

Organism UniProt Comment Textmining
Chromobacterium violaceum
-
-
-
Pseudomonas aeruginosa
-
-
-
Pseudomonas aeruginosa
-
wild-type PAO1
-
Pseudomonas aeruginosa PAO1A4
-
-
-
Pseudomonas fluorescens
-
-
-
Pseudomonas fluorescens CHA0
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glycine + O2
-
Pseudomonas fluorescens HCN + CO2 + H2O
-
?
glycine + O2
-
Pseudomonas aeruginosa HCN + CO2 + H2O
-
?
glycine + O2
-
Chromobacterium violaceum HCN + CO2 + H2O
-
?
glycine + O2
-
Pseudomonas aeruginosa PAO1A4 HCN + CO2 + H2O
-
?
glycine + O2
-
Pseudomonas fluorescens CHA0 HCN + CO2 + H2O
-
?
glycine + O2
-
Pseudomonas fluorescens HCN + CO2 + 2 H2O
-
?
glycine + O2
-
Pseudomonas aeruginosa HCN + CO2 + 2 H2O
-
?
glycine + O2
-
Chromobacterium violaceum HCN + CO2 + 2 H2O
-
?
glycine + O2
-
Pseudomonas aeruginosa PAO1A4 HCN + CO2 + 2 H2O
-
?
glycine + O2
-
Pseudomonas fluorescens CHA0 HCN + CO2 + 2 H2O
-
?