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Literature summary for 1.4.99.5 extracted from

  • Broderick, K.E.; Chan, A.; Balasubramanian, M.; Feala, J.; Reed, S.L.; Panda, M.; Sharma, V.S.; Pilz, R.B.; Bigby, T.D.; Boss, G.R.
    Cyanide produced by human isolates of Pseudomonas aeruginosa contributes to lethality in Drosophila melanogaster (2008), J. Infect. Dis., 197, 457-464.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glycine + FAD Pseudomonas aeruginosa glycine is decarboxylated to HCN by the enzyme HCN synthase, the product of the hcnABC synthase gene cluster HCN + CO2 + FADH2
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 ?
additional information Pseudomonas aeruginosa cyanide produced by the enzyme is involved in virulence of the organism. Drosophila melanogaster exposed to cyanogenic Pseudomonas aeruginosa strains have high cyanide and low ATP concentrations in body extracts, and treatment with a cyanide antidote equalized survival of flies injected with cyanogenic and noncyanogenic strains. Strain PAO1 with a mutation in the hydrogen cyanide synthase gene cluster is much less toxic to flies than the parental cyanogenic strain or 2 knock-in strains, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
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 human isolates, cyanogenic strains, hcnABC synthase gene cluster
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glycine + FAD glycine is decarboxylated to HCN by the enzyme HCN synthase, the product of the hcnABC synthase gene cluster Pseudomonas aeruginosa HCN + CO2 + FADH2
-
 ?
additional information cyanide produced by the enzyme is involved in virulence of the organism. Drosophila melanogaster exposed to cyanogenic Pseudomonas aeruginosa strains have high cyanide and low ATP concentrations in body extracts, and treatment with a cyanide antidote equalized survival of flies injected with cyanogenic and noncyanogenic strains. Strain PAO1 with a mutation in the hydrogen cyanide synthase gene cluster is much less toxic to flies than the parental cyanogenic strain or 2 knock-in strains, overview Pseudomonas aeruginosa ?
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 ?

Synonyms

Synonyms Comment Organism
HCN synthase
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 Pseudomonas aeruginosa

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
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 in vivo assay at Pseudomonas aeruginosa

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Pseudomonas aeruginosa