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Literature summary for 1.4.99.6 extracted from

  • Ouedraogo, D.; Ball, J.; Iyer, A.; Reis, R.A.G.; Vodovoz, M.; Gadda, G.
    Amine oxidation by D-arginine dehydrogenase in Pseudomonas aeruginosa (2017), Arch. Biochem. Biophys., 632, 192-201 .
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
structure without added D-amino acids, to 1.06 A resolution, and in presence of D-arginine and D-histidine Pseudomonas aeruginosa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.06
-
D-arginine pH 8.7, 25°C Pseudomonas aeruginosa
0.26
-
D-Lysine pH 8.7, 25°C Pseudomonas aeruginosa
0.8
-
D-tyrosine pH 8.7, 25°C Pseudomonas aeruginosa
10
-
D-methionine pH 8.7, 25°C Pseudomonas aeruginosa
11
-
D-phenylalanine pH 8.7, 25°C Pseudomonas aeruginosa
11
-
D-histidine pH 8.7, 25°C Pseudomonas aeruginosa
12
-
D-leucine pH 8.7, 25°C Pseudomonas aeruginosa

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa Q9HXE3
-
-
Pseudomonas aeruginosa DSM 22644 Q9HXE3
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-alanine + phenazine methosulfate + H2O
-
Pseudomonas aeruginosa pyruvate + NH3 + reduced phenazine methosulfate
-
?
D-alanine + phenazine methosulfate + H2O
-
Pseudomonas aeruginosa DSM 22644 pyruvate + NH3 + reduced phenazine methosulfate
-
?
D-arginine + phenazine methosulfate + H2O
-
Pseudomonas aeruginosa 5-guanidino-2-oxopentanoate + NH3 + reduced phenazine methosulfate
-
?
D-arginine + phenazine methosulfate + H2O
-
Pseudomonas aeruginosa DSM 22644 5-guanidino-2-oxopentanoate + NH3 + reduced phenazine methosulfate
-
?
D-asparagine + phenazine methosulfate + H2O
-
Pseudomonas aeruginosa 2-oxobutanedioate + NH3 + reduced phenazine methosulfate
-
?
D-asparagine + phenazine methosulfate + H2O
-
Pseudomonas aeruginosa DSM 22644 2-oxobutanedioate + NH3 + reduced phenazine methosulfate
-
?
D-glutamine + phenazine methosulfate + H2O
-
Pseudomonas aeruginosa 5-amino-2,5-dioxopentanoate + NH3 + reduced phenazine methosulfate
-
?
D-glutamine + phenazine methosulfate + H2O
-
Pseudomonas aeruginosa DSM 22644 5-amino-2,5-dioxopentanoate + NH3 + reduced phenazine methosulfate
-
?
D-histidine + phenazine methosulfate + H2O
-
Pseudomonas aeruginosa 3-(1H-imidazol-4-yl)-2-oxopropanoate + NH3 + reduced phenazine methosulfate
-
?
D-isoleucine + phenazine methosulfate + H2O
-
Pseudomonas aeruginosa 3-methyl-2-oxopentanoate + NH3 + reduced phenazine methosulfate
-
?
D-leucine + phenazine methosulfate + H2O
-
Pseudomonas aeruginosa 4-methyl-2-oxopentanoate + NH3 + reduced phenazine methosulfate
-
?
D-lysine + phenazine methosulfate + H2O
-
Pseudomonas aeruginosa 7-amino-2-oxoheptanoic acid + NH3 + reduced phenazine methosulfate
-
?
D-methionine + phenazine methosulfate + H2O
-
Pseudomonas aeruginosa 4-methylsulfanyl-2-oxobutanoate + NH3 + reduced phenazine methosulfate
-
?
D-phenylalanine + phenazine methosulfate + H2O
-
Pseudomonas aeruginosa 2-oxo-3-phenylpropanoate + NH3 + reduced phenazine methosulfate
-
?
D-proline + phenazine methosulfate + H2O
-
Pseudomonas aeruginosa DELTA1-pyrroline-2-carboxylate + NH3 + reduced phenazine methosulfate
-
?
D-serine + phenazine methosulfate + H2O
-
Pseudomonas aeruginosa 3-hydroxy-2-oxopropanoate + NH3 + reduced phenazine methosulfate
-
?
D-threonine + phenazine methosulfate + H2O
-
Pseudomonas aeruginosa 3-hydroxy-2-oxobutanoate + NH3 + reduced phenazine methosulfate
-
?
D-tryptophan + phenazine methosulfate + H2O
-
Pseudomonas aeruginosa 3-indole-2-oxopropanoate + NH3 + reduced phenazine methosulfate
-
?
D-tyrosine + phenazine methosulfate + H2O
-
Pseudomonas aeruginosa (4-hydroxyphenyl)pyruvate + NH3 + reduced phenazine methosulfate
-
?
D-valine + phenazine methosulfate + H2O
-
Pseudomonas aeruginosa 2-oxopentanoate + NH3 + reduced phenazine methosulfate
-
?
additional information no substrates: aspartae, glutamate Pseudomonas aeruginosa ?
-
-
additional information no substrates: aspartae, glutamate Pseudomonas aeruginosa DSM 22644 ?
-
-

Synonyms

Synonyms Comment Organism
DADH
-
Pseudomonas aeruginosa

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
6.4
-
D-leucine pH 8.7, 25°C Pseudomonas aeruginosa
23
-
D-tyrosine pH 8.7, 25°C Pseudomonas aeruginosa
35
-
D-histidine pH 8.7, 25°C Pseudomonas aeruginosa
75
-
D-phenylalanine pH 8.7, 25°C Pseudomonas aeruginosa
141
-
D-Lysine pH 8.7, 25°C Pseudomonas aeruginosa
154
-
D-methionine pH 8.7, 25°C Pseudomonas aeruginosa
204
-
D-arginine pH 8.7, 25°C Pseudomonas aeruginosa

Cofactor

Cofactor Comment Organism Structure
FAD contains a noncovalently linked FAD Pseudomonas aeruginosa

General Information

General Information Comment Organism
metabolism DADH catalyzes an asynchronous CH and NH bond cleavage via a hydride transfer mechanism. The enzyme follows a ping-pong bibi mechanism. The shape and flexibility of loop L1 in the active site of DADH are important for substrate capture and broad substrate specificity Pseudomonas aeruginosa

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.00075
-
D-threonine pH 8.7, 25°C Pseudomonas aeruginosa
0.0038
-
D-serine pH 8.7, 25°C Pseudomonas aeruginosa
0.016
-
D-asparagine pH 8.7, 25°C Pseudomonas aeruginosa
0.041
-
D-alanine pH 8.7, 25°C Pseudomonas aeruginosa
0.047
-
D-valine pH 8.7, 25°C Pseudomonas aeruginosa
0.186
-
D-glutamine pH 8.7, 25°C Pseudomonas aeruginosa
0.195
-
D-isoleucine pH 8.7, 25°C Pseudomonas aeruginosa
0.245
-
D-tryptophan pH 8.7, 25°C Pseudomonas aeruginosa
0.42
-
D-proline pH 8.7, 25°C Pseudomonas aeruginosa
0.515
-
D-leucine pH 8.7, 25°C Pseudomonas aeruginosa
3.14
-
D-histidine pH 8.7, 25°C Pseudomonas aeruginosa
6.9
-
D-phenylalanine pH 8.7, 25°C Pseudomonas aeruginosa
14.8
-
D-methionine pH 8.7, 25°C Pseudomonas aeruginosa
27.6
-
D-tyrosine pH 8.7, 25°C Pseudomonas aeruginosa
530
-
D-Lysine pH 8.7, 25°C Pseudomonas aeruginosa
3400
-
D-arginine pH 8.7, 25°C Pseudomonas aeruginosa