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Literature summary for 1.5.1.15 extracted from

  • Di Pietro, E.; Wang, X.L.; MacKenzie, R.E.
    The expression of mitochondrial methylenetetrahydrofolate dehydrogenase-cyclohydrolase supports a role in rapid cell growth (2004), Biochim. Biophys. Acta, 1674, 78-84.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information construction of a gene deletion mutant cell line, the cells can survive in liver and other tissues because the null defect is rescued by metabolites supplied by surrounding normal cells Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Mus musculus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5,10-methylenetetrahydrofolate + NAD+ Mus musculus enzyme provides one-carbon units for purine synthesis during embryogenesis, metabolism overview 5,10-methenyltetrahydrofolate + NADH
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus P18155 gene nmdmc
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo enzyme is mainly expressed during embryogenesis for purine synthesis Mus musculus
-
liver
-
Mus musculus
-
additional information expression pattern analysis, elevated enzyme expression in tumour cells due to different folate-mediated support of purine synthesis compared to normal cells Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,10-methylenetetrahydrofolate + NAD+
-
Mus musculus 5,10-methenyltetrahydrofolate + NADH
-
?
5,10-methylenetetrahydrofolate + NAD+ enzyme provides one-carbon units for purine synthesis during embryogenesis, metabolism overview Mus musculus 5,10-methenyltetrahydrofolate + NADH
-
?

Synonyms

Synonyms Comment Organism
methylenetetrahydrofolate dehydrogenase-cyclohydrolase
-
Mus musculus
NMDMC
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
NAD+ dependent on Mus musculus