BRENDA - Enzyme Database
show all sequences of 1.5.1.2

DELTA1-pyrroline-5-carboxylate reductase as a new target for therapeutics: inhibition of the enzyme from Streptococcus pyogenes and effects in vivo

Forlani, G.; Petrollino, D.; Fusetti, M.; Romanini, L.; Nocek, B.; Joachimiak, A.; Berlicki, L.; Kafarski, P.; Amino Acids 42, 2283-2291 (2012)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
([[3,5-bis(trifluoromethyl)phenyl]amino]methanediyl)bis(phosphonic acid)
71.2% inhibition at 0.2 mM
Streptococcus pyogenes
[[(2,3-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
95.4% inhibition at 0.2 mM
Streptococcus pyogenes
[[(2,4-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
52% inhibition at 0.2 mM
Streptococcus pyogenes
[[(2,5-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
63.9% inhibition at 0.2 mM
Streptococcus pyogenes
[[(2,6-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
96.2% inhibition at 0.2 mM
Streptococcus pyogenes
[[(3,4-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
92.5% inhibition at 0.2 mM
Streptococcus pyogenes
[[(3,5-dibromophenyl)amino]methanediyl]bis(phosphonic acid)
98.4% inhibition at 0.2 mM
Streptococcus pyogenes
[[(3,5-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
91.1% inhibition at 0.2 mM
Streptococcus pyogenes
[[(3,5-dimethylphenyl)amino]methanediyl]bis(phosphonic acid)
70.5% inhibition at 0.2 mM
Streptococcus pyogenes
[[(3-chlorophenyl)amino]methanediyl]bis(phosphonic acid)
71.2% inhibition at 0.2 mM
Streptococcus pyogenes
[[(4-benzylphenyl)amino]methanediyl]bis(phosphonic acid)
94.5% inhibition at 0.2 mM
Streptococcus pyogenes
[[(4-chlorophenyl)amino]methanediyl]bis(phosphonic acid)
61.5% inhibition at 0.2 mM
Streptococcus pyogenes
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1-pyrroline-5-carboxylate + NAD(P)H + H+
Streptococcus pyogenes
-
L-proline + NAD(P)+
-
-
?
1-pyrroline-5-carboxylate + NAD(P)H + H+
Streptococcus pyogenes ATCC 19615
-
L-proline + NAD(P)+
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Streptococcus pyogenes
-
-
-
Streptococcus pyogenes ATCC 19615
-
-
-
Purification (Commentary)
Commentary
Organism
nickel affinity gel column chromatography
Streptococcus pyogenes
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1-pyrroline-5-carboxylate + NAD(P)H + H+
-
723917
Streptococcus pyogenes
L-proline + NAD(P)+
-
-
-
?
1-pyrroline-5-carboxylate + NAD(P)H + H+
-
723917
Streptococcus pyogenes ATCC 19615
L-proline + NAD(P)+
-
-
-
?
1-pyrroline-5-carboxylate + NADH + H+
-
723917
Streptococcus pyogenes
L-proline + NAD+
-
-
-
?
1-pyrroline-5-carboxylate + NADH + H+
-
723917
Streptococcus pyogenes ATCC 19615
L-proline + NAD+
-
-
-
?
Cofactor
Cofactor
Commentary
Organism
Structure
NADH
-
Streptococcus pyogenes
NADPH
-
Streptococcus pyogenes
IC50 Value
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.00022
-
pH 7.5-8.0, at 37°C
Streptococcus pyogenes
[[(3,5-dibromophenyl)amino]methanediyl]bis(phosphonic acid)
0.00022
-
pH 7.5-8.0, at 37°C
Streptococcus pyogenes
[[(3,5-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
0.00039
-
pH 7.5-8.0, at 37°C
Streptococcus pyogenes
[[(3,4-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
0.00041
-
pH 7.5-8.0, at 37°C
Streptococcus pyogenes
[[(4-benzylphenyl)amino]methanediyl]bis(phosphonic acid)
0.00078
-
pH 7.5-8.0, at 37°C
Streptococcus pyogenes
([[3,5-bis(trifluoromethyl)phenyl]amino]methanediyl)bis(phosphonic acid)
0.00087
-
pH 7.5-8.0, at 37°C
Streptococcus pyogenes
[[(2,3-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
0.00088
-
pH 7.5-8.0, at 37°C
Streptococcus pyogenes
[[(2,6-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
0.0009
-
pH 7.5-8.0, at 37°C
Streptococcus pyogenes
[[(3-chlorophenyl)amino]methanediyl]bis(phosphonic acid)
0.0014
-
pH 7.5-8.0, at 37°C
Streptococcus pyogenes
[[(4-chlorophenyl)amino]methanediyl]bis(phosphonic acid)
0.0027
-
pH 7.5-8.0, at 37°C
Streptococcus pyogenes
[[(2,5-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
0.012
-
pH 7.5-8.0, at 37°C
Streptococcus pyogenes
[[(2,4-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
0.0256
-
pH 7.5-8.0, at 37°C
Streptococcus pyogenes
[[(3,5-dimethylphenyl)amino]methanediyl]bis(phosphonic acid)
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADH
-
Streptococcus pyogenes
NADPH
-
Streptococcus pyogenes
IC50 Value (protein specific)
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.00022
-
pH 7.5-8.0, at 37°C
Streptococcus pyogenes
[[(3,5-dibromophenyl)amino]methanediyl]bis(phosphonic acid)
0.00022
-
pH 7.5-8.0, at 37°C
Streptococcus pyogenes
[[(3,5-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
0.00039
-
pH 7.5-8.0, at 37°C
Streptococcus pyogenes
[[(3,4-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
0.00041
-
pH 7.5-8.0, at 37°C
Streptococcus pyogenes
[[(4-benzylphenyl)amino]methanediyl]bis(phosphonic acid)
0.00078
-
pH 7.5-8.0, at 37°C
Streptococcus pyogenes
([[3,5-bis(trifluoromethyl)phenyl]amino]methanediyl)bis(phosphonic acid)
0.00087
-
pH 7.5-8.0, at 37°C
Streptococcus pyogenes
[[(2,3-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
0.00088
-
pH 7.5-8.0, at 37°C
Streptococcus pyogenes
[[(2,6-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
0.0009
-
pH 7.5-8.0, at 37°C
Streptococcus pyogenes
[[(3-chlorophenyl)amino]methanediyl]bis(phosphonic acid)
0.0014
-
pH 7.5-8.0, at 37°C
Streptococcus pyogenes
[[(4-chlorophenyl)amino]methanediyl]bis(phosphonic acid)
0.0027
-
pH 7.5-8.0, at 37°C
Streptococcus pyogenes
[[(2,5-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
0.012
-
pH 7.5-8.0, at 37°C
Streptococcus pyogenes
[[(2,4-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
0.0256
-
pH 7.5-8.0, at 37°C
Streptococcus pyogenes
[[(3,5-dimethylphenyl)amino]methanediyl]bis(phosphonic acid)
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
([[3,5-bis(trifluoromethyl)phenyl]amino]methanediyl)bis(phosphonic acid)
71.2% inhibition at 0.2 mM
Streptococcus pyogenes
[[(2,3-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
95.4% inhibition at 0.2 mM
Streptococcus pyogenes
[[(2,4-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
52% inhibition at 0.2 mM
Streptococcus pyogenes
[[(2,5-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
63.9% inhibition at 0.2 mM
Streptococcus pyogenes
[[(2,6-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
96.2% inhibition at 0.2 mM
Streptococcus pyogenes
[[(3,4-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
92.5% inhibition at 0.2 mM
Streptococcus pyogenes
[[(3,5-dibromophenyl)amino]methanediyl]bis(phosphonic acid)
98.4% inhibition at 0.2 mM
Streptococcus pyogenes
[[(3,5-dichlorophenyl)amino]methanediyl]bis(phosphonic acid)
91.1% inhibition at 0.2 mM
Streptococcus pyogenes
[[(3,5-dimethylphenyl)amino]methanediyl]bis(phosphonic acid)
70.5% inhibition at 0.2 mM
Streptococcus pyogenes
[[(3-chlorophenyl)amino]methanediyl]bis(phosphonic acid)
71.2% inhibition at 0.2 mM
Streptococcus pyogenes
[[(4-benzylphenyl)amino]methanediyl]bis(phosphonic acid)
94.5% inhibition at 0.2 mM
Streptococcus pyogenes
[[(4-chlorophenyl)amino]methanediyl]bis(phosphonic acid)
61.5% inhibition at 0.2 mM
Streptococcus pyogenes
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1-pyrroline-5-carboxylate + NAD(P)H + H+
Streptococcus pyogenes
-
L-proline + NAD(P)+
-
-
?
1-pyrroline-5-carboxylate + NAD(P)H + H+
Streptococcus pyogenes ATCC 19615
-
L-proline + NAD(P)+
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
nickel affinity gel column chromatography
Streptococcus pyogenes
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1-pyrroline-5-carboxylate + NAD(P)H + H+
-
723917
Streptococcus pyogenes
L-proline + NAD(P)+
-
-
-
?
1-pyrroline-5-carboxylate + NAD(P)H + H+
-
723917
Streptococcus pyogenes ATCC 19615
L-proline + NAD(P)+
-
-
-
?
1-pyrroline-5-carboxylate + NADH + H+
-
723917
Streptococcus pyogenes
L-proline + NAD+
-
-
-
?
1-pyrroline-5-carboxylate + NADH + H+
-
723917
Streptococcus pyogenes ATCC 19615
L-proline + NAD+
-
-
-
?
Other publictions for EC 1.5.1.2
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
740763
Christensen
Resolving the cofactor-binding ...
Homo sapiens
J. Biol. Chem.
292
7233-7243
2017
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1
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1
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2
1
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5
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5
5
740491
Ruszkowski
The structure of Medicago trun ...
Medicago truncatula
Front. Plant Sci.
6
869
2015
1
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1
1
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1
4
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2
1
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2
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2
2
740831
Struys
Human pyrroline-5-carboxylate ...
Homo sapiens
J. Inherit. Metab. Dis.
37
327-332
2014
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-
-
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2
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2
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2
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741069
Giberti
delta1-Pyrroline-5-carboxylate ...
Arabidopsis thaliana
New Phytol.
202
911-919
2014
-
-
1
-
-
-
4
4
-
2
2
-
-
4
-
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-
1
-
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2
1
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2
2
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2
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1
4
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1
2
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4
4
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4
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2
2
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1
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2
1
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2
2
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1
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725183
Forlani
Synthesis and evaluation of ef ...
Arabidopsis thaliana
J. Agric. Food Chem.
61
6792-6798
2013
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26
-
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1
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1
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1
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2
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26
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2
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26
26
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1
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1
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726110
Singh
Proline biosynthesizing enzyme ...
Anabaena sp., Anabaena sp. PCC 7120
Physiol. Mol. Biol. Plants
19
521-528
2013
-
-
1
-
-
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1
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23
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1
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2
1
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2
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1
2
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1
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1
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2
1
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-
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-
723917
Forlani
DELTA1-pyrroline-5-carboxylate ...
Streptococcus pyogenes, Streptococcus pyogenes ATCC 19615
Amino Acids
42
2283-2291
2012
-
-
-
-
-
-
12
-
-
-
-
2
-
2
-
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1
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-
-
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-
4
-
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2
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12
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2
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12
12
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2
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1
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4
-
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723922
Petrollino
Coenzyme preference of Strepto ...
Streptococcus pyogenes
Amino Acids
43
493-497
2012
-
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1
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3
4
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1
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2
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2
1
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2
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1
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1
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3
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4
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2
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2
1
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711685
Zabirnyk
Oxidized low-density lipoprote ...
Homo sapiens
Carcinogenesis
31
446-454
2010
-
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1
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7
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7
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1
1
1
1
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713158
Liu
miR-23b targets proline oxidas ...
Homo sapiens
Oncogene
29
4914-4924
2010
-
1
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2
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6
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6
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1
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1
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695442
Guernsey
Mutation in pyrroline-5-carbox ...
Homo sapiens
Am. J. Hum. Genet.
85
120-129
2009
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1
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1
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2
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701063
Meng
Purification, characterization ...
Saccharolobus solfataricus, Saccharolobus solfataricus P2
Protein Expr. Purif.
64
125-130
2009
-
-
1
1
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1
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2
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4
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1
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6
1
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2
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2
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4
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1
4
1
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1
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2
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1
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6
1
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2
-
2
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-
704292
Fonknechten
A conserved gene cluster rules ...
Acetoanaerobium sticklandii
J. Bacteriol.
191
3162-3167
2009
-
-
-
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1
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1
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1
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1
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1
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1
1
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-
689728
Phang
PPARgamma and proline oxidase ...
Homo sapiens
PPAR Res.
2008
542694
2008
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1
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1
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686421
Veeranagamallaiah
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Glutamine synthetase expressio ...
Setaria italica
Environ. Exp. Bot.
60
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2007
1
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674605
Pandhare
Proline oxidase, a proapoptoti ...
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9
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Meng
Crystal structure of human pyr ...
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1
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2
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676262
Liu
Proline oxidase activates both ...
Homo sapiens
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25
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2006
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676952
Yang
Purification and characterizat ...
Mycobacterium tuberculosis
Protein Expr. Purif.
45
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2006
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1
1
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4
6
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2
2
1
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3
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1
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4
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2
1
1
1
2
9
2
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1
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6
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2
1
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4
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2
1
1
1
2
9
2
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676969
Meng
Purification, characterization ...
Homo sapiens
Protein Expr. Purif.
49
83-87
2006
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1
1
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1
1
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1
1
1
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3
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4
1
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1
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4
1
2
1
1
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1
1
1
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672935
Liu
MnSOD inhibits proline oxidase ...
Homo sapiens
Carcinogenesis
26
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2005
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1
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1
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674464
Rivera
The p53-induced gene-6 (prolin ...
Homo sapiens
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29346-29354
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3
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1
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Nocek
Crystal structures of delta1-p ...
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354
91-106
2005
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2
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2
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2
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2
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2
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2
2
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654887
Haslett
Assay and subcellular localiza ...
Rattus norvegicus
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2004
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2
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1
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2
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655592
Kamiya
Hepatocyte nuclear factors 1al ...
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FEBS Lett.
578
63-68
2004
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1
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1
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1
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656198
Maxwell
Proline oxidase induces apopto ...
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J. Biol. Chem.
278
9784-9789
2003
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1
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392143
Fujii
Biotransformation of L-lysine ...
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66
622-627
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1
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1
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3
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392066
Donald
Proline oxidase, encoded by p5 ...
Homo sapiens
Cancer Res.
61
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2001
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1
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1
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392140
Deutch
Oxidation of L-thiazolidine-4- ...
Escherichia coli
Curr. Microbiol.
42
442-446
2001
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1
3
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1
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3
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1
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1
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1
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392148
Murahama
Purification and characterizat ...
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2
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1
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2
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2
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1
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1
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392146
Kenklies
-
Proline biosynthesis from L-or ...
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Microbiology
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1999
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392065
Fahmy
Enzymes of DELTA1-pyrroline-5- ...
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Comp. Biochem. Physiol. B
118
229-237
1997
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392139
Chilson
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Pyrroline-5-carboxylate reduct ...
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1997
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392145
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Developmental regulation of py ...
Arabidopsis thaliana
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392138
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Pyrroline-5-carboxylate reduct ...
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392137
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Osmoregulation of a pyrroline- ...
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392144
Hayward
The sluggish-A gene of Drosoph ...
Drosophila melanogaster
Proc. Natl. Acad. Sci. USA
90
2979-2983
1993
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392147
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Reduction of DELTA1-pyrroline- ...
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392106
Kohl
Activities of the pentose phos ...
Arachis hypogaea, Cajanus cajan, Glycine max, Lupinus luteus, Medicago sativa, Phaseolus vulgaris, Pisum sativum, Vigna unguiculata
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Hull
Cloning and physical character ...
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Rayapati
Pyrroline-5-carboxylate reduct ...
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392108
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Pyrroline-5-carboxylate reduct ...
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Kohl
Proline metabolism in N2-fixin ...
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Hagedorn
Demonstration of a NADPH-linke ...
Rattus norvegicus
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1
-
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1
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392112
Shiono
Purification and characterizat ...
Rattus norvegicus
Biochim. Biophys. Acta
881
72-78
1986
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8
6
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2
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2
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1
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2
1
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1
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5
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8
5
6
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2
1
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1
1
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1
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1
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392113
Krueger
Purification to homogeneity of ...
Hordeum vulgare
Plant Physiol.
80
142-144
1986
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2
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3
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1
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1
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1
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2
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2
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1
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1
1
1
5
1
-
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1
1
1
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392114
Elthon
Effects of the proline analog ...
Hordeum vulgare, Vigna radiata
Plant Physiol.
74
213-218
1984
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-
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2
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2
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2
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2
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2
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2
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-
392115
Hagedorn
Transfer of reducing equivalen ...
Rattus norvegicus
Arch. Biochem. Biophys.
225
95-101
1983
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-
-
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1
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1
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1
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-
392116
Deutch
Escherichia coli delta 1-pyrro ...
Escherichia coli
Nucleic Acids Res.
10
7701-7714
1982
-
-
1
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-
-
-
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-
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3
-
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3
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1
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1
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1
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1
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1
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-
392117
Matsuzawa
Purification and characterizat ...
Bos taurus
Biochim. Biophys. Acta
717
215-219
1982
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-
-
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2
3
-
2
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2
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1
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2
2
1
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1
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1
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2
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2
1
3
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2
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1
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2
2
1
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-
1
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-
-
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-
-
-
-
392118
Matsuzawa
Delta 1-pyrroline-5-carboxylat ...
Saccharomyces cerevisiae
Biochim. Biophys. Acta
616
381-383
1980
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-
-
-
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2
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1
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1
1
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1
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1
1
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-
-
-
-
392119
Matsuzawa
Delta 1-Pyrroline-5-carboxylat ...
Saccharomyces cerevisiae
Biochim. Biophys. Acta
613
318-323
1980
-
-
-
-
-
1
3
3
-
-
1
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-
3
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1
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2
1
1
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1
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1
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3
-
3
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1
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1
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2
1
1
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-
1
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-
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-
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-
392120
Tsuyama
The distribution of pyrroline ...
Aldrichina grahami
Experientia
36
1037-1038
1980
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2
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2
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4
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4
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-
392121
Yeh
The function of pyrroline-5-ca ...
Homo sapiens
Biochem. Biophys. Res. Commun.
94
450-457
1980
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-
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2
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2
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3
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1
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-
-
390310
Krishna
Biosynthesis of proline in Pse ...
Pseudomonas aeruginosa
Biochem. J.
181
223-230
1979
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-
-
-
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9
4
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1
1
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2
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1
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2
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2
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1
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2
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2
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9
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4
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1
1
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1
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2
-
2
-
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-
1
-
-
-
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-
392123
Costilow
Identity of proline dehydrogen ...
Clostridium sporogenes
J. Bacteriol.
134
139-146
1978
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-
-
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4
-
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1
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1
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1
1
1
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1
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2
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2
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2
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4
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1
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1
1
1
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1
-
2
-
-
-
-
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-
-
-
-
392047
Herzfeld
Enzymes metabolizing delta1-py ...
Rattus norvegicus
Biochem. J.
166
95-103
1977
-
-
-
-
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2
2
1
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2
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1
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2
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1
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2
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2
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2
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2
1
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1
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2
-
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-
1
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-
392126
Rossi
Partial purification and some ...
Escherichia coli
J. Bacteriol.
129
108-114
1977
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5
3
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1
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3
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1
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1
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1
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3
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2
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2
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3
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1
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1
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1
-
1
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3
-
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-
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-
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392125
Miler
-
Pyrroline-5-carboxylic acid re ...
Glycine max
Phytochemistry
15
1855-1857
1976
-
-
-
-
-
1
11
3
-
-
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1
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1
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1
1
2
1
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1
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2
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2
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1
-
11
-
3
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1
-
1
1
2
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
392127
Rena
-
Proline dehydrogenase and pyrr ...
Cucurbita moschata
Phytochemistry
14
657-661
1975
-
-
-
-
-
-
13
-
-
-
1
-
-
1
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-
1
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1
1
1
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1
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2
2
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-
13
-
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1
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1
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1
1
1
-
-
-
-
1
-
2
2
-
-
-
-
-
-
-
-
392128
Valle
Proline inhibition of pyrrolin ...
Cricetulus griseus, Homo sapiens, Rattus norvegicus
Biochem. Biophys. Res. Commun.
54
1418-1424
1973
-
-
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3
1
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4
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5
2
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3
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3
3
1
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5
2
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-
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-
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392129
Phang
A radioisotopic assay for delt ...
Rattus norvegicus
Anal. Biochem.
55
266-271
1973
-
-
-
-
-
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1
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2
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1
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2
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-
1
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-
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-
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-
-
-
-
392130
Splittstoesser
-
Pyrroline-5-carboxylate reduct ...
Cucurbita maxima, Cucurbita moschata
Phytochemistry
12
1565-1568
1973
1
-
-
-
-
-
12
2
2
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-
2
-
-
-
-
-
2
1
-
2
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-
1
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-
4
-
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-
1
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-
4
-
-
-
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12
-
2
2
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2
1
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
392131
Strecker
-
DELTA1-pyrroline-5-carboxylate ...
Bos taurus
Methods Enzymol.
17B
258-261
1971
-
-
-
-
-
-
12
1
-
-
-
-
-
1
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-
1
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-
1
1
-
1
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1
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1
2
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-
2
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-
12
-
1
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1
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1
1
-
1
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
171971
Hill
The biosynthesis of proline by ...
Tetrahymena pyriformis
Biochim. Biophys. Acta
148
435-447
1967
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-
-
-
-
-
-
-
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1
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1
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-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
392136
Noguchi
-
Determination of P5C reductase ...
Nicotiana tabacum
Agric. Biol. Chem.
30
452
1966
-
-
-
-
-
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-
1
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1
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1
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-
-
-
-
-
-
-
-
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-
-
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-
-
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-
-
392132
Adams
Hydroxyproline metabolism. III ...
Bos taurus
J. Biol. Chem.
235
3499-3503
1960
-
-
-
-
-
-
4
1
-
-
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1
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1
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-
1
1
2
-
-
-
-
-
1
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-
2
-
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-
2
-
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4
-
1
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-
1
-
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1
1
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
392133
Yura
Pyrroline-5-carboxylate reduct ...
Escherichia coli, Neurospora crassa
J. Biol. Chem.
234
335-338
1959
-
-
-
-
-
-
-
3
1
-
-
1
-
3
-
-
1
-
-
-
2
-
3
-
-
-
-
-
2
-
-
4
-
-
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-
4
-
-
-
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-
3
1
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-
1
-
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-
1
-
-
2
-
3
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
392038
Meister
Enzymatic synthesis of L-pipec ...
Pisum sativum, Rattus norvegicus, Vigna radiata var. radiata
J. Biol. Chem.
229
789-800
1957
-
-
-
-
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-
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-
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-
-
3
-
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-
2
-
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3
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-
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2
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3
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