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Literature summary for 1.5.1.20 extracted from
- Methylenetetrahydrofolate reductase and methionine synthase: biochemistry and molecular biology (1998), Eur. J. Pediatr., 157, 54-59.
No PubMed abstract available
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| A177V | enzyme is thermolabile | Escherichia coli |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| S-adenosylmethionine | - |
Homo sapiens |  |
| S-adenosylmethionine | allosteric inhibition | Sus scrofa | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 77000 | - |
2 * 77000 | Homo sapiens |
| 77000 | - |
2 * 77000 | Sus scrofa |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Sus scrofa | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5,10-methylenetetrahydrofolate + NADPH | - |
Homo sapiens | 5-methyltetrahydrofolate + NADP+ | - |
? | |
| 5,10-methylenetetrahydrofolate + NADPH | - |
Sus scrofa | 5-methyltetrahydrofolate + NADP+ | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 77000 | Homo sapiens |
| dimer | 2 * 77000 | Sus scrofa |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Homo sapiens | |
| FAD | non covalently bound | Sus scrofa | |
| FAD | flavoprotein with non-covalently bound FAD | Escherichia coli | |
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