Activating Compound | Comment | Organism | Structure |
---|---|---|---|
A23187 | treatment of cells results in increase in enzyme mRNA and protein | Mus musculus | |
homocysteine | treatment of cells results in increase in enzyme mRNA and protein | Mus musculus | |
inositol-requiring enzyme-1 | the induction of MTHFR was also observed after overexpression of inositol-requiring enzyme-1 | Mus musculus | |
additional information | transfection of c-Jun and two activators of c-Jun (LiCl and sodium valproate) increase MTHFR expression, MTHFR mRNA is up-regulated by endoplasmic reticulum stress | Mus musculus | |
additional information | induction of MTHFR is observed after overexpression of inositol-requiring enzyme IRE1 and is inhibited by a dominant-negative mutant of IRE1. Tranfection of c-Jun and its activators LiCl and sodium valproate increase MTHFR expression, whereas inhibitor of c-Jun SP600125 reduces activation | Mus musculus | |
thapsigargin | treatment of cells results in increase in enzyme mRNA and protein | Mus musculus | |
tunicamycin | treatment of cells results in increase in enzyme mRNA and protein | Mus musculus |
Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli and Neuro-2a cells | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | inhibited by a dominant-negative mutant of inositol-requiring enzyme-1, a reported inhibitor of c-Jun (SP600125) and a dominant-negative derivative of c-Jun N-terminal kinase-1 reduce MTHFR activation | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Neuro-2a cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,10-methylenetetrahydrofolate + reduced acceptor | - |
Mus musculus | 5-methyltetrahydrofolate + oxidized acceptor | - |
? |
Synonyms | Comment | Organism |
---|---|---|
methylenetetrahydrofolate reductase | - |
Mus musculus |
MTHFR | - |
Mus musculus |