Literature summary for 1.5.1.20 extracted from

Villela, M.P.; Andrade, V.L.; Eccard, B.; Jordao, A.A.; Sertorio, J.T.; Tanus-Santos, J.E.; Silva, I.F.; Silveira, J.N.; Sandrim, V.C.
Homocysteine and nitrite levels are modulated by MTHFR 677C>T polymorphism in obese women treated with simvastatin (2014), Clin. Exp. Pharmacol. Physiol., 41, 744-747 .

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Application

Application	Comment	Organism
medicine	obese women without comorbidities and carrying the T variant of the 677C>T (p.A222V) polymorphism of gene MTHFR exhibit benefits with simvastatin treatment, mainly in terms of increased NO levels	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
A222V	the 677C>T polymorphism located in methylenetetrahydrofolate reductase (NAD(P)H) (MTHFR) gene modulates the effects of this treatment on homocysteine and nitrite (as a biomarker of nitric oxide bioavailability) in obese women treated with simvastatin. Simvastatin treatment significantly reduces total cholesterol, low density lipoprotein-cholesterol, thiobarbituric acid-reactive substances, high-sensitivity C-reactive protein and homocysteine, whereas nitrite levels are increased. The reduction in homocysteine levels in carriers of the T allele is 20.3% compared with -9.4% in patients with the CC genotype. Importantly, before treatment, nitrite levels are significantly higher in patients with the CC genotype compared with T allele carriers, whereas after treatment these levels are similar between groups	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P42898	-	-

Synonyms

Synonyms	Comment	Organism
MTHFR	-	Homo sapiens

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Release 2023.1 (January 2023)