Inhibitors | Comment | Organism | Structure |
---|---|---|---|
methotrexate | 50% inhibition at 0.000000436 mM, recombinant rat-derived enzyme, 50% inhibition at 0.0000029 mM, recombinant human-derived enzyme | Pneumocystis jirovecii | |
OAAG324 | i.e. 6-([(2,5-dichlorophenyl)amino]methyl)pyrido[2,3-d]pyrimidine-2,4-diamine, 50% inhibition at 0.000262 mM, recombinant rat-derived enzyme, 50% inhibition at 0.0075 mM, recombinant human-derived enzyme | Pneumocystis jirovecii | |
OAAG373 | i.e. 6-([(3,4,5-trichlorophenyl)amino]methyl)pyrido[2,3-d]pyrimidine-2,4-diamine, 50% inhibition at 0.000139 mM, recombinant rat-derived enzyme, 50% inhibition at 0.00094 mM, recombinant human-derived enzyme | Pneumocystis jirovecii | |
PY957 | i.e. 5-(3-[(2,4-diaminopyrimidin-5-yl)methyl]-4-methoxyphenoxy)pentanoic acid, 50% inhibition at 0.00009833 mM, recombinant rat-derived enzyme | Pneumocystis jirovecii | |
pyrimethamine | 50% inhibition at 0.0024 mM, recombinant rat-derived enzyme, 50% inhibition at 0.0021 mM, recombinant human-derived enzyme | Pneumocystis jirovecii | |
trimethoprim | 50% inhibition at 0.027 mM, recombinant rat-derived enzyme, 50% inhibition at 0.0032 mM, recombinant human-derived enzyme | Pneumocystis jirovecii |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.002 | - |
7,8-dihydrofolate | His-tagged human-derived enzyme, pH 7.65 | Pneumocystis jirovecii | |
0.0056 | - |
7,8-dihydrofolate | recombinant rat-derived enzyme, pH 7.65 | Pneumocystis jirovecii | |
0.0065 | - |
NADPH | His-tagged human-derived enzyme, pH 7.65 | Pneumocystis jirovecii | |
0.0106 | - |
7,8-dihydrofolate | native rat-derived enzyme, pH 7.65 | Pneumocystis jirovecii | |
0.0123 | - |
NADPH | recombinant rat-derived enzyme, pH 7.65 | Pneumocystis jirovecii | |
0.0167 | - |
NADPH | native rat-derived enzyme, pH 7.65 | Pneumocystis jirovecii |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pneumocystis jirovecii | - |
recombinant human-derived and rat-derived enzyme | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
7,8-dihydrofolate + NADPH | - |
Pneumocystis jirovecii | 5,6,7,8-tetrahydrofolate + NADP+ | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Pneumocystis jirovecii | |
NADPH | - |
Pneumocystis jirovecii |