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Literature summary for 1.5.1.3 extracted from

  • Tahar, R.; Basco, L.K.
    Molecular epidemiology of malaria in Cameroon. XXVII. Clinical and parasitological response to sulfadoxine-pyrimethamine treatment and Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase alleles in Cameroonian children (2007), Acta Trop., 103, 81-89.
    View publication on PubMed

Application

Application Comment Organism
medicine study on the association between the clinical and parasitological response to sulfadoxinepyrimethamine and allelic combinations of dihydrofolate reductase and dihydropteroate synthase genes. Determination of dihydrofolate reductase and dihydropteroate synthase genotypes is of limited value to predict the treatment outcome in individual patients, mostly due to few treatment failures and few wild-type haplotypes. The majority of clinical isolates is characterized as quadruple, i.e. 196 isolates with mutations N51I-C59R-S108N in dihydrofolate reductase and A437G dihydropteroate synthase, or triple mutants, i.e. 97 isolates with mutations N51I-C59R-S108N in dihydrofolate reductase and wild-type dihydropteroate synthase, or S108N + N51I or C59R in dihydrofolate reductase and A437G in dihydropteroate synthase. Wild-type, single mutation, and double mutation were observed in 29, 20, and 13 parasites, respectively Plasmodium falciparum

Protein Variants

Protein Variants Comment Organism
N51I/C59R/S108N natural mutants isolated in a study on the association between the clinical and parasitological response to sulfadoxinepyrimethamine and allelic combinations of dihydrofolate reductase and dihydropteroate synthase genes. The majority of clinical isolates is characterized as quadruple, i.e. 196 isolates with mutations N51I-C59R-S108N in dihydrofolate reductase and A437G dihydropteroate synthase Plasmodium falciparum
S108N/C59R natural mutants isolated in a study on the association between the clinical and parasitological response to sulfadoxinepyrimethamine and allelic combinations of dihydrofolate reductase and dihydropteroate synthase genes Plasmodium falciparum
S108N/N51I natural mutants isolated in a study on the association between the clinical and parasitological response to sulfadoxinepyrimethamine and allelic combinations of dihydrofolate reductase and dihydropteroate synthase genes Plasmodium falciparum

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
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