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Literature summary for 1.5.1.3 extracted from

  • Seujange, Y.; Eiam-Ong, S.; Tirawatnapong, T.; Eiam-Ong, S.
    Role of angiotensin II on dihydrofolate reductase, GTP-cyclohydrolase 1 and nitric oxide synthase expressions in renal ischemia-reperfusion (2008), Am. J. Nephrol., 28, 692-700.
    View publication on PubMed

Application

Application Comment Organism
medicine renal ischemia-reperfusion decreases dihydrofolate reductase mRNA and protein levels, both of which are restored by angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker, whereas GTP-cyclohydrolase 1 expression is unaltered. Renal ischemia-reperfusion suppresses endothelial nitric oxide synthase dimer while enhancing the monomer and augments inducible nitric oxide synthase mRNA, total inducible nitric oxide synthase protein and monomer, which are attenuated by angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q920D2
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Source Tissue

Source Tissue Comment Organism Textmining
kidney
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Rattus norvegicus
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