Literature summary for 1.5.1.3 extracted from

Raman, J.; Sharp, B.; Kleinschmidt, I.; Roper, C.; Streat, E.; Kelly, V.; Barnes, K.I.
Differential effect of regional drug pressure on dihydrofolate reductase and dihydropteroate synthetase mutations in southern Mozambique (2008), Am. J. Trop. Med. Hyg., 78, 256-261.

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Application

Application	Comment	Organism
medicine	study on prevalence and frequency of dihydrofolate reductase and dihydropteroate synthetase mutations associated with sulfadoxine-pyrimethamine resistance at surveillance sites in Southern Mozambique. Frequency of dihydrofolate triple mutation increased from 0.26 in 1999 to 0.96 in 2003, remaining high in 2004. Parasites with both dihydrofolate reductase triple mutation and dihydropteroate synthetase double mutations had increased in 2001, but decreased by 2004. The peaking of sulfadoxine-pyrimethamine resistance markers in 2001 coincided with a sulfadoxine-pyrimethamine resistant malaria epidemic in neighboring regions	Plasmodium falciparum

Organism

Organism	UniProt	Comment	Textmining
Plasmodium falciparum	-	isolates from southern Mozambique	-

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Release 2023.1 (January 2023)