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Literature summary for 1.5.1.3 extracted from

  • Dulucq, S.; St-Onge, G.; Gagne, V.; Ansari, M.; Sinnett, D.; Labuda, D.; Moghrabi, A.; Krajinovic, M.
    DNA variants in the dihydrofolate reductase gene and outcome in childhood ALL (2008), Blood, 111, 3692-3700.
    View publication on PubMed

Application

Application Comment Organism
medicine study on the association of polymorphisms in dihydrofolate reductase gene and treatment response in children with acute lymphoblastic leukemia. Lower event-free survival is associated with homozygosity for the allele A-317 and C-1610, and with the haplotype *1, and mRNA analysis shows higher dihydrofolate reductase levels for haplotype *1 carriers Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information study on the association of polymorphisms in dihydrofolate reductase gene and treatment response in children with acute lymphoblastic leukemia. Lower event-free survival is associated with homozygosity for the allele A-317 and C-1610, and with the haplotype *1, and mRNA analysis shows higher dihydrofolate reductase levels for haplotype *1 carriers Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
children with acute lymphoblastic leukemia
-