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Literature summary for 1.5.1.3 extracted from

  • Izbicka, E.; Diaz, A.; Streeper, R.; Wick, M.; Campos, D.; Steffen, R.; Saunders, M.
    Distinct mechanistic activity profile of pralatrexate in comparison to other antifolates in in vitro and in vivo models of human cancers (2009), Cancer Chemother. Pharmacol., 64, 993-999.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.5.1.3

Inhibitors

Inhibitors Comment Organism Structure
methotrexate
-
 Homo sapiens
pemetrexed
-
 Homo sapiens
pralatrexate
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
NCI-H460 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7,8-dihydrofolate + NADPH + H+
-
 Homo sapiens 5,6,7,8-tetrahydrofolate + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
DHFR
-
 Homo sapiens
dihydrofolate reductase
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 pemetrexed value above 0.0002 mM Homo sapiens
0.000026
-
 methotrexate
-
 Homo sapiens
0.000045
-
 pralatrexate
-
 Homo sapiens