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Literature summary for 1.5.1.3 extracted from

  • Kao, T.T.; Tu, H.C.; Chang, W.N.; Chen, B.H.; Shi, Y.Y.; Chang, T.C.; Fu, T.F.
    Grape seed extract inhibits the growth and pathogenicity of Staphylococcus aureus by interfering with dihydrofolate reductase activity and folate-mediated one-carbon metabolism (2010), Int. J. Food Microbiol., 141, 17-27.
    View publication on PubMed

Application

Application Comment Organism
medicine significantly reduced inflammatory responses and mortality are observed in zebrafish infected with Staphylococcus aureus pre-incubated with grape seed extract. Grape seed extract might serve as an effective natural alternative for the control of food poisoning caused by Staphylococcus aureus with proper safety measure Staphylococcus aureus

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli as a His-tagged fusion protein Staphylococcus aureus

Inhibitors

Inhibitors Comment Organism Structure
grape seed extract grape seed extract inhibits the dihydrofolate reductase activity and growth of Staphylococcus aureus. The grape seed extract-induced growth inhibition is reversed by adding, tetrahydrofolate, 5,10-methylenetetrahydrofolate or methionine to the medium Staphylococcus aureus

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dihydrofolate + NADPH + H+
-
Staphylococcus aureus tetrahydrofolate + NADP+
-
?

Synonyms

Synonyms Comment Organism
DHFR
-
Staphylococcus aureus
dihydrofolate reductase
-
Staphylococcus aureus