Literature summary for 1.5.1.33 extracted from

Mpamhanga, C.P.; Spinks, D.; Tulloch, L.B.; Shanks, E.J.; Robinson, D.A.; Collie, I.T.; Fairlamb, A.H.; Wyatt, P.G.; Frearson, J.A.; Hunter, W.N.; Gilbert, I.H.; Brenk, R.
One scaffold, three binding modes: novel and selective pteridine reductase 1 inhibitors derived from fragment hits discovered by virtual screening (2009), J. Med. Chem., 52, 4454-4465.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
-	Trypanosoma brucei

Organism

Organism	UniProt	Comment	Textmining
Trypanosoma brucei	O76290	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Trypanosoma brucei

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
dihydrobiopterin + NADPH	-	Trypanosoma brucei	5,6,7,8-tetrahydrobiopterin + NADP+	-	r

Synonyms

Synonyms	Comment	Organism
pteridine reductase 1	-	Trypanosoma brucei
PTR1	-	Trypanosoma brucei

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.01	-	2-amino-6-chloro-benzimidazole	-	Trypanosoma brucei
0.021	-	2,4-diaminoquinazoline	called compound 2	Trypanosoma brucei
0.141	-	2,4-diaminopyrimidine	called compound 3	Trypanosoma brucei

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Release 2023.1 (January 2023)