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Literature summary for 1.5.1.34 extracted from

  • Shen, R.S.
    Inhibition of dihydropteridine reductase by catecholamines and related compounds (1983), Biochim. Biophys. Acta, 743, 129-135.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
3-iodotyrosine weak inhibition Homo sapiens
3-O-methyldopamine 0.06 mM, 50% inhibition Homo sapiens
3-O-Methylepinephrine 0.18 mM, 50% inhibition Homo sapiens
4-O-Methyldopamine 0.069 mM, 50% inhibition Homo sapiens
5-Hydroxydopamine 0.042 mM, 50% inhibition Homo sapiens
6-Hydroxydopamine 0.029 mM, 50% inhibition Homo sapiens
alpha-Methyltyrosine 1.1 mM, 50% inhibition Homo sapiens
catecholamine
-
Homo sapiens
dopamine
-
Homo sapiens
epinephrine 0.13 mM, 50% inhibition Homo sapiens
L-beta-3,4-dihydroxyphenylalanine 0.02 mM, 50% inhibition Homo sapiens
L-tyrosine 0.44 mM, 50% inhibition Homo sapiens
N-Methyldopamine 0.027 mM, 50% inhibition Homo sapiens
norepinephrine 0.2 mM, 50% inhibition Homo sapiens
octopamine 0.19 mM, 50% inhibition Homo sapiens
tyramine IC50: 0.04 mM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.007
-
dopamine noncompetitive vs. NADH Homo sapiens
0.014
-
dopamine noncompetitive vs. quinonoid 2-amino-6,7-dimethyl-4-hydroxydihydropteridine Homo sapiens
0.016
-
norepinephrine noncompetitive vs. NADH Homo sapiens
0.024
-
tyramine noncompetitive vs. NADH Homo sapiens
0.024
-
6-Hydroxydopamine noncompetitive vs. quinonoid 2-amino-6,7-dimethyl-4-hydroxydihydropteridine and NADH Homo sapiens
0.05
-
tyramine noncompetitive vs. quinonoid 2-amino-6,7-dimethyl-4-hydroxydihydropteridine Homo sapiens
0.11
-
epinephrine noncompetitive vs. quinonoid 2-amino-6,7-dimethyl-4-hydroxydihydropteridine Homo sapiens
0.14
-
epinephrine noncompetitive vs. NADH Homo sapiens
0.19
-
norepinephrine noncompetitive vs. quinonoid 2-amino-6,7-dimethyl-4-hydroxydihydropteridine Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.04
-
IC50: 0.04 mM Homo sapiens tyramine