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Literature summary for 1.5.1.34 extracted from

  • Hasse, S.; Gibbons, N.C.; Rokos, H.; Marles, L.K.; Schallreuter, K.U.
    Perturbed 6-tetrahydrobiopterin recycling via decreased dihydropteridine reductase in vitiligo: more evidence for H2O2 stress (2004), J. Invest. Dermatol., 122, 307-313.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
H2O2 regulatory function in vivo, above 0.03 mM, oxidation of Met146 and Met151 leads to inactivation of the enzyme due to disruption of the NADH-binding site Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6,7-dihydropteridine + NADH Homo sapiens last step of recycling of the cofactor (6R)-L-erythro-5,6,7,8-tetrahydrobiopteridine essential for aromatic amino acid hydroxylases and nitric oxide synthases, regulatory mechanism involve H2O2, enzyme inactivation because of H2O2 accumulation in the epidermis contributes to the pathomechanism of vitiligo (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P09417 patients with vitiligo
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
Homo sapiens
-
lymphocyte
-
Homo sapiens
-
monocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6,7-dihydropteridine + NADH
-
Homo sapiens (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD+
-
?
6,7-dihydropteridine + NADH last step of recycling of the cofactor (6R)-L-erythro-5,6,7,8-tetrahydrobiopteridine essential for aromatic amino acid hydroxylases and nitric oxide synthases, regulatory mechanism involve H2O2, enzyme inactivation because of H2O2 accumulation in the epidermis contributes to the pathomechanism of vitiligo Homo sapiens (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD+
-
?

Synonyms

Synonyms Comment Organism
DHPR
-
Homo sapiens
dihydropteridine reductase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADH
-
Homo sapiens