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Literature summary for 1.5.1.50 extracted from
- Investigation of osmolyte effects on FolM: comparison with other dihydrofolate reductases (2014), Biochemistry, 53, 1330-1341.
General Stability
| General Stability | Organism |
|---|---|
| presence of betaine increases the stability of isoform FolM | Escherichia coli |
Organic Solvent Stability
| Organic Solvent | Comment | Organism |
|---|---|---|
| DMSO | both DMSO and ethylene glycol decrease the stability of isoform FolM | Escherichia coli |
| Ethylene glycol | both DMSO and ethylene glycol decrease the stability of isoform FolM | Escherichia coli |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | P0AFS3 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | isoform FolM possesses weak dihydrofolate reductase activity, EC 1.5.1.3 | Escherichia coli | ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| FolM | - |
Escherichia coli |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | cofactor binding increases in presence of betaine, and weakens in presence of ethylene glycol and polyethylene glycol 400 | Escherichia coli | |
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Release 2023.1 (January 2023)
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