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Literature summary for 1.5.1.52 extracted from

  • Ghssein, G.; Brutesco, C.; Ouerdane, L.; Fojcik, C.; Izaute, A.; Wang, S.; Hajjar, C.; Lobinski, R.; Lemaire, D.; Richaud, P.; Voulhoux, R.; Espaillat, A.; Cava, F.; Pignol, D.; Borezee-Durant, E.; Arnoux, P.
    Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus (2016), Science, 352, 1105-1109 .
    View publication on PubMed
Search for more literature for 1.5.1.52

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(2S)-2-amino-4-[[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino]butanoate + pyruvate + NADPH + H+ Staphylococcus aureus the enzyme catalyses the last reaction in the biosynthesis of the metallophore staphylopine, which is involved in the acquisition of nickel, copper, and cobalt staphylopine + NADP+ + H2O
-
 ?
(2S)-2-amino-4-[[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino]butanoate + pyruvate + NADPH + H+ Staphylococcus aureus ATCC 700699 the enzyme catalyses the last reaction in the biosynthesis of the metallophore staphylopine, which is involved in the acquisition of nickel, copper, and cobalt staphylopine + NADP+ + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus A0A0H3JT80
-
-
Staphylococcus aureus ATCC 700699 A0A0H3JT80
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2S)-2-amino-4-[[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino]butanoate + pyruvate + NADPH + H+
-
 Staphylococcus aureus staphylopine + NADP+ + H2O
-
 ?
(2S)-2-amino-4-[[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino]butanoate + pyruvate + NADPH + H+ the enzyme catalyses the last reaction in the biosynthesis of the metallophore staphylopine, which is involved in the acquisition of nickel, copper, and cobalt Staphylococcus aureus staphylopine + NADP+ + H2O
-
 ?
(2S)-2-amino-4-[[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino]butanoate + pyruvate + NADPH + H+
-
 Staphylococcus aureus ATCC 700699 staphylopine + NADP+ + H2O
-
 ?
(2S)-2-amino-4-[[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino]butanoate + pyruvate + NADPH + H+ the enzyme catalyses the last reaction in the biosynthesis of the metallophore staphylopine, which is involved in the acquisition of nickel, copper, and cobalt Staphylococcus aureus ATCC 700699 staphylopine + NADP+ + H2O
-
 ?

Synonyms

Synonyms Comment Organism
cntM
-
 Staphylococcus aureus
sav2468
-
 Staphylococcus aureus

Cofactor

Cofactor Comment Organism Structure
NADPH the enzyme is specific for NADPH Staphylococcus aureus

General Information

General Information Comment Organism
metabolism the enzyme catalyses the last reaction in the biosynthesis of the metallophore staphylopine, which is involved in the acquisition of nickel, copper, and cobalt Staphylococcus aureus
physiological function the enzyme catalyses the last reaction in the biosynthesis of the metallophore staphylopine, which is involved in the acquisition of nickel, copper, and cobalt Staphylococcus aureus