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Literature summary for 1.5.1.53 extracted from
- Inhibition of pig liver methylenetetrahydrofolate reductase by dihydrofolate some mechanistic and regulatory implications (1979), Biochemistry, 18, 4845-4851 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5,10-methylenetetrahydrofolate | substrate inhibition | Sus scrofa |  |
| 5-methyl-5,6-dihydrofolate | - |
Sus scrofa | |
| dihydrofolate | competitive with respect to methylenetetrahydrofolate | Sus scrofa | |
| folic acid | - |
Sus scrofa | |
| methenyltetrahydrofolate | - |
Sus scrofa | |
| methyltetrahydrofolate | - |
Sus scrofa | |
| tetrahydrofolate | - |
Sus scrofa | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.016 | - |
NADPH | pH 6.7, 25°C | Sus scrofa | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5,10-methylenetetrahydrofolate + NADPH + H+ | Sus scrofa | - |
5-methyltetrahydrofolate + NADP+ | - |
? | |
| 5-methyltetrahydrofolate + oxidized menadione | Sus scrofa | - |
5,10-methylenetetrahydrofolate + reduced menadione | - |
? | |
| additional information | Sus scrofa | no substrate: dihydrofolate | ? | - |
- |
|
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Sus scrofa | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5,10-methylenetetrahydrofolate + NADPH + H+ | - |
Sus scrofa | 5-methyltetrahydrofolate + NADP+ | - |
? | |
| 5-methyltetrahydrofolate + oxidized menadione | - |
Sus scrofa | 5,10-methylenetetrahydrofolate + reduced menadione | - |
? | |
| additional information | no substrate: dihydrofolate | Sus scrofa | ? | - |
- |
|
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Sus scrofa | |
| NADPH | - |
Sus scrofa | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.006 | - |
dihydrofolate | pH 6.7, 25°C | Sus scrofa | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | enzyme exhibits ping-pong bi-bi kinetics | Sus scrofa |
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