Literature summary for 1.5.1.53 extracted from

Spellicy, C.J.; Northrup, H.; Fletcher, J.M.; Cirino, P.T.; Dennis, M.; Morrison, A.C.; Martinez, C.A.; Au, K.S.
Folate metabolism gene 5,10-methylenetetrahydrofolate reductase (MTHFR) is associated with ADHD in myelomeningocele patients (2012), PLoS ONE, 7, e51330 .

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Application

Application	Comment	Organism
medicine	testing of 478 individuals with myelomeningocele for attention-deficit hyperactivity disorder (ADHD) behavior plus genotyping for seven single nucleotide polymorphisms in the MTHFR gene. 28.7% of myelomeningocele participants exhibit rating scale elevations consistent with ADHD, of these 70.1% have scores consistent with the predominantly inattentive subtype. There is a positive association between the SNP rs4846049 in the 39-untranslated region of the MTHFR gene and the attention-deficit hyperactivity disorder phenotype in myelomeningocele participants	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P42898	cf. EC 1.5.1.20	-

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Release 2023.1 (January 2023)