Any feedback?
Literature summary for 1.5.1.6 extracted from
- Folate and 10-formyltetrahydrofolate dehydrogenase in human and rat retina: Relation to methanol toxicity (1996), Toxicol. Appl. Pharmacol., 141, 373-381.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | formic acidemia: toxicity of methanol in humans is correlated with formate accumulation as a result of low rates of formate oxidation, which is in vivo dependent on enzyme activity and on hepatic tetrahydrofolate levels | Homo sapiens |
| medicine | methanol-induced toxicity in Müller cells of the retina, role of 10-FDH in formate intoxination both as a protectant and as a toxicity-provoking element | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | comparable amounts of cytosolic and mitochondrial FDH in retinal tissues | Homo sapiens | 5829 | - |
| cytosol | comparable amounts of cytosolic and mitochondrial FDH in retinal tissues | Rattus norvegicus | 5829 | - |
| mitochondrion | comparable amounts of cytosolic and mitochondrial FDH in retinal tissues | Homo sapiens | 5739 | - |
| mitochondrion | comparable amounts of cytosolic and mitochondrial FDH in retinal tissues | Rattus norvegicus | 5739 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 10-formyltetrahydrofolate + NADP+ + H2O | Homo sapiens | folate-dependent metabolism of formate to carbon dioxide | tetrahydrofolate + CO2 + NADPH + H+ | - |
? |  |
| 10-formyltetrahydrofolate + NADP+ + H2O | Rattus norvegicus | folate-dependent metabolism of formate to carbon dioxide | tetrahydrofolate + CO2 + NADPH + H+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
Sprague-Dawley rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
| retina | much lower levels than in liver, preferentially localized in Müller cells, FDH levels in human retina are higher than in rat retina, folate levels in human retina are 14% of those in rat retina | Homo sapiens | - |
| retina | much lower levels than in liver, preferentially localized in Müller cells, FDH levels in human retina are higher than in rat retina, folate levels in human retina are 14% of those in rat retina | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 10-formyltetrahydrofolate + NADP+ + H2O | - |
Homo sapiens | tetrahydrofolate + CO2 + NADPH + H+ | - |
? | |
| 10-formyltetrahydrofolate + NADP+ + H2O | - |
Rattus norvegicus | tetrahydrofolate + CO2 + NADPH + H+ | - |
? | |
| 10-formyltetrahydrofolate + NADP+ + H2O | folate-dependent metabolism of formate to carbon dioxide | Homo sapiens | tetrahydrofolate + CO2 + NADPH + H+ | - |
? | |
| 10-formyltetrahydrofolate + NADP+ + H2O | folate-dependent metabolism of formate to carbon dioxide | Rattus norvegicus | tetrahydrofolate + CO2 + NADPH + H+ | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| 10-formyltetrahydrofolate | 10-formyltetrahydrofolate | Homo sapiens | |
| 10-formyltetrahydrofolate | 10-formyltetrahydrofolate | Rattus norvegicus | |
| tetrahydrofolate | - |
Homo sapiens | |
| tetrahydrofolate | - |
Rattus norvegicus | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
