Literature summary for 1.5.1.7 extracted from

Burk, D.L.; Hwang, J.; Kwok, E.; Marrone, L.; Goodfellow, V.; Dmitrienko, G.I.; Berghuis, A.M.
Structural studies of the final enzyme in the alpha-aminoadipate pathway-saccharopine dehydrogenase from Saccharomyces cerevisiae (2007), J. Mol. Biol., 373, 745-754.

Search for more literature for 1.5.1.7

Application

Application	Comment	Organism
medicine	target for antimicrobial drug development	Saccharomyces cerevisiae

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli B834(DE3) cells	Saccharomyces cerevisiae

Crystallization (Commentary)

Crystallization (Comment)	Organism
in complex with NAD+ and saccharopine, hanging drop vapour diffusion method in 20% (w/v) PEG 8000, 0.1 M MES (pH 6.0), and 0.2 M Ca(OAc)2	Saccharomyces cerevisiae

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	P38998	-	-

Purification (Commentary)

Purification (Comment)	Organism
glutathione Sepharose column chromatography	Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O	-	Saccharomyces cerevisiae	L-lysine + 2-oxoglutarate + NADH + H+	-	?

Synonyms

Synonyms	Comment	Organism
SDH	-	Saccharomyces cerevisiae

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)