Literature summary for 1.5.3.1 extracted from

Watanabe, G.; Nakajima, D.; Hiroshima, A.; Suzuki, H.; Yoneda, S.
Analysis of water channels by molecular dynamics simulation of heterotetrameric sarcosine oxidase (2015), Biophys. Physicobiol., 12, 131-137 .

Search for more literature for 1.5.3.1

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
sarcosine + H2O + O2	Corynebacterium sp. U-96	-	glycine + formaldehyde + H2O2	-	?

Organism

Organism	UniProt	Comment	Textmining
Corynebacterium sp. U-96	Q50LF0 and Q50LF2 and Q50LF1 and Q50LE9	Q50LF0: subunit alpha, Q50LF2: subunit beta, Q50LF1: subunit delta, Q50LE9: subunit gamma	-

Reaction

Reaction	Comment	Organism	Reaction ID
sarcosine + H2O + O2 = glycine + formaldehyde + H2O2	molecular dynamics simulation study for the heterotetrameric sarcosine oxidase-dimethylglycine complex gives insight to understand the dynamics of the enzyme. A cluster analysis on the small rectangular cells with high water probabilities results in the detection of eleven water channels. CH1, CH2, CH3, and CH4 correspond to the tunnels from the large cavity in the previous study. CH6, CH7, and the combined CH8 and CH9 are narrow channels from the large cavity. CH5 and the combined CH10 and CH11 are not connected with the cavity. No permeation of water molecules between the channels is found except in the combined channels. The results of the present analysis are consistent with the selective transport hypothesis	Corynebacterium sp. U-96	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
sarcosine + H2O + O2	-	Corynebacterium sp. U-96	glycine + formaldehyde + H2O2	-	?

Subunits

Subunits	Comment	Organism
heterotetramer	-	Corynebacterium sp. U-96

Cofactor

Cofactor	Comment	Organism	Structure
FAD	flavoprotein. The flavin is both covalently and non-covalently bound in a molar ratio of 1:1	Corynebacterium sp. U-96

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Release 2023.1 (January 2023)