Literature summary for 1.5.3.1 extracted from

Abe, Y.; Shoji, M.; Nishiya, Y.; Aiba, H.; Kishimoto, T.; Kitaura, K.
The reaction mechanism of sarcosine oxidase elucidated using FMO and QM/MM methods (2017), Phys. Chem. Chem. Phys., 19, 9811-9822 .

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Organism

Organism	UniProt	Comment	Textmining
Bacillus sp. B-0618	P40859	-	-

Synonyms

Synonyms	Comment	Organism
SoxA	-	Bacillus sp. B-0618

General Information

General Information	Comment	Organism
metabolism	hydride-transfer is the most energetically favorable mechanism. Hydrogen is not transferred in the hydride state (H-) but in a hydrogen atom state. A single electron is simultaneously transferred from sarcosine to flavin through their overlapping orbitals, the reaction mechanism can be labeled the hydrogen-atom coupled electron-transfer (HACET) mechanism. Sarcosine is moved close to the flavin ring because of a small charge transfer and the positively charged residues (Arg49, Arg52, and Lys348) near the active site play a prominent role in stabilizing the sarcosine-flavin complex	Bacillus sp. B-0618

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Release 2023.1 (January 2023)