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Literature summary for 1.5.3.13 extracted from

  • Keinaenen, T.A.; Grigorenko, N.; Khomutov, A.R.; Huang, Q.; Uimari, A.; Alhonen, L.; Hyvoenen, M.T.; Vepsaelaeinen, J.
    Controlling the regioselectivity and stereospecificity of FAD-dependent polyamine oxidases with the use of amine-attached guide molecules as conformational modulators (2018), Biosci. Rep., 38, BSR20180527 .
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
synthesis application of simple guide molecules, being either covalently attached to polyamines or used as a supplement to the substrate mixtures, for controlling the enzyme's regioselectivity and stereospecificity Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0002
-
N1-benzoyl-(S)-alpha-methylspermidine pH 9, 25°C Homo sapiens
0.0008
-
N-[(2S)-4-[(4-aminobutyl)amino]butan-2-yl]pyridine-4-carboxamide pH 9, 25°C Homo sapiens
0.0012
-
N1-benzoyl-(R)-alpha-methylspermidine pH 9, 25°C Homo sapiens
0.0016
-
N1-phenyl-(R)-alpha-methylspermidine pH 9, 25°C Homo sapiens
0.002
-
N1-phenyl-(R)-alpha-methylspermidine pH 9, 25°C Homo sapiens
0.0036
-
N-[(2R)-4-[(4-aminobutyl)amino]butan-2-yl]pyridine-4-carboxamide pH 9, 25°C Homo sapiens
0.0082
-
N1-acetylspermidine pH 9, 25°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
peroxisome
-
Homo sapiens 5777
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q6QHF9
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PAOX naturally metabolizes achiral N1-acetylated polyamines, displays aldehyde-controllable stereospecificity with chiral 1-methylated polyamines, like (R)- and (S)-1-methylspermidine Homo sapiens ?
-
-
N-[(2R)-4-[(4-aminobutyl)amino]butan-2-yl]pyridine-4-carboxamide + O2 + H2O
-
Homo sapiens putrescine + (3R)-3-[(pyridin-4-yl)amino]butanal + H2O2
-
?
N-[(2S)-4-[(4-aminobutyl)amino]butan-2-yl]pyridine-4-carboxamide + O2 + H2O
-
Homo sapiens putrescine + (3S)-3-[(pyridin-4-yl)amino]butanal + H2O2
-
?
N1-acetylspermidine + O2 + H2O
-
Homo sapiens putrescine + 3-acetamidopropanal + H2O2
-
?
N1-benzoyl-(R)-alpha-methylspermidine + O2 + H2O
-
Homo sapiens putrescine + N-[(2R)-4-oxobutan-2-yl]benzamide + H2O2
-
?
N1-benzoyl-(S)-alpha-methylspermidine + O2 + H2O
-
Homo sapiens putrescine + N-[(2S)-4-oxobutan-2-yl]benzamide + H2O2
-
?
N1-phenyl-(R)-alpha-methylspermidine + O2 + H2O
-
Homo sapiens putrescine + (3R)-3-anilinobutanal + H2O2
-
?
N1-phenyl-(S)-alpha-methylspermidine + O2 + H2O
-
Homo sapiens putrescine + (3S)-3-anilinobutanal + H2O2
-
?

Synonyms

Synonyms Comment Organism
APAO
-
Homo sapiens
PAOX
-
Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.00001
-
N-[(2S)-4-[(4-aminobutyl)amino]butan-2-yl]pyridine-4-carboxamide pH 9, 25°C Homo sapiens
0.00003
-
N1-phenyl-(R)-alpha-methylspermidine pH 9, 25°C Homo sapiens
0.00014
-
N1-phenyl-(R)-alpha-methylspermidine pH 9, 25°C Homo sapiens
0.0052
-
N-[(2R)-4-[(4-aminobutyl)amino]butan-2-yl]pyridine-4-carboxamide pH 9, 25°C Homo sapiens
0.03
-
N1-benzoyl-(S)-alpha-methylspermidine pH 9, 25°C Homo sapiens
2.7
-
N1-acetylspermidine pH 9, 25°C Homo sapiens
4.6
-
N1-benzoyl-(R)-alpha-methylspermidine pH 9, 25°C Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
18
-
N-[(2S)-4-[(4-aminobutyl)amino]butan-2-yl]pyridine-4-carboxamide pH 9, 25°C Homo sapiens
18
-
N1-phenyl-(R)-alpha-methylspermidine pH 9, 25°C Homo sapiens
71
-
N1-phenyl-(R)-alpha-methylspermidine pH 9, 25°C Homo sapiens
150
-
N1-benzoyl-(S)-alpha-methylspermidine pH 9, 25°C Homo sapiens
330
-
N1-acetylspermidine pH 9, 25°C Homo sapiens
1400
-
N-[(2R)-4-[(4-aminobutyl)amino]butan-2-yl]pyridine-4-carboxamide pH 9, 25°C Homo sapiens
3800
-
N1-benzoyl-(R)-alpha-methylspermidine pH 9, 25°C Homo sapiens