Application | Comment | Organism |
---|---|---|
synthesis | application of simple guide molecules, being either covalently attached to polyamines or used as a supplement to the substrate mixtures, for controlling the enzyme's regioselectivity and stereospecificity | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0002 | - |
N1-benzoyl-(S)-alpha-methylspermidine | pH 9, 25°C | Homo sapiens | |
0.0008 | - |
N-[(2S)-4-[(4-aminobutyl)amino]butan-2-yl]pyridine-4-carboxamide | pH 9, 25°C | Homo sapiens | |
0.0012 | - |
N1-benzoyl-(R)-alpha-methylspermidine | pH 9, 25°C | Homo sapiens | |
0.0016 | - |
N1-phenyl-(R)-alpha-methylspermidine | pH 9, 25°C | Homo sapiens | |
0.002 | - |
N1-phenyl-(R)-alpha-methylspermidine | pH 9, 25°C | Homo sapiens | |
0.0036 | - |
N-[(2R)-4-[(4-aminobutyl)amino]butan-2-yl]pyridine-4-carboxamide | pH 9, 25°C | Homo sapiens | |
0.0082 | - |
N1-acetylspermidine | pH 9, 25°C | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
peroxisome | - |
Homo sapiens | 5777 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q6QHF9 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | PAOX naturally metabolizes achiral N1-acetylated polyamines, displays aldehyde-controllable stereospecificity with chiral 1-methylated polyamines, like (R)- and (S)-1-methylspermidine | Homo sapiens | ? | - |
- |
|
N-[(2R)-4-[(4-aminobutyl)amino]butan-2-yl]pyridine-4-carboxamide + O2 + H2O | - |
Homo sapiens | putrescine + (3R)-3-[(pyridin-4-yl)amino]butanal + H2O2 | - |
? | |
N-[(2S)-4-[(4-aminobutyl)amino]butan-2-yl]pyridine-4-carboxamide + O2 + H2O | - |
Homo sapiens | putrescine + (3S)-3-[(pyridin-4-yl)amino]butanal + H2O2 | - |
? | |
N1-acetylspermidine + O2 + H2O | - |
Homo sapiens | putrescine + 3-acetamidopropanal + H2O2 | - |
? | |
N1-benzoyl-(R)-alpha-methylspermidine + O2 + H2O | - |
Homo sapiens | putrescine + N-[(2R)-4-oxobutan-2-yl]benzamide + H2O2 | - |
? | |
N1-benzoyl-(S)-alpha-methylspermidine + O2 + H2O | - |
Homo sapiens | putrescine + N-[(2S)-4-oxobutan-2-yl]benzamide + H2O2 | - |
? | |
N1-phenyl-(R)-alpha-methylspermidine + O2 + H2O | - |
Homo sapiens | putrescine + (3R)-3-anilinobutanal + H2O2 | - |
? | |
N1-phenyl-(S)-alpha-methylspermidine + O2 + H2O | - |
Homo sapiens | putrescine + (3S)-3-anilinobutanal + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
APAO | - |
Homo sapiens |
PAOX | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00001 | - |
N-[(2S)-4-[(4-aminobutyl)amino]butan-2-yl]pyridine-4-carboxamide | pH 9, 25°C | Homo sapiens | |
0.00003 | - |
N1-phenyl-(R)-alpha-methylspermidine | pH 9, 25°C | Homo sapiens | |
0.00014 | - |
N1-phenyl-(R)-alpha-methylspermidine | pH 9, 25°C | Homo sapiens | |
0.0052 | - |
N-[(2R)-4-[(4-aminobutyl)amino]butan-2-yl]pyridine-4-carboxamide | pH 9, 25°C | Homo sapiens | |
0.03 | - |
N1-benzoyl-(S)-alpha-methylspermidine | pH 9, 25°C | Homo sapiens | |
2.7 | - |
N1-acetylspermidine | pH 9, 25°C | Homo sapiens | |
4.6 | - |
N1-benzoyl-(R)-alpha-methylspermidine | pH 9, 25°C | Homo sapiens |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
18 | - |
N-[(2S)-4-[(4-aminobutyl)amino]butan-2-yl]pyridine-4-carboxamide | pH 9, 25°C | Homo sapiens | |
18 | - |
N1-phenyl-(R)-alpha-methylspermidine | pH 9, 25°C | Homo sapiens | |
71 | - |
N1-phenyl-(R)-alpha-methylspermidine | pH 9, 25°C | Homo sapiens | |
150 | - |
N1-benzoyl-(S)-alpha-methylspermidine | pH 9, 25°C | Homo sapiens | |
330 | - |
N1-acetylspermidine | pH 9, 25°C | Homo sapiens | |
1400 | - |
N-[(2R)-4-[(4-aminobutyl)amino]butan-2-yl]pyridine-4-carboxamide | pH 9, 25°C | Homo sapiens | |
3800 | - |
N1-benzoyl-(R)-alpha-methylspermidine | pH 9, 25°C | Homo sapiens |