Application | Comment | Organism |
---|---|---|
medicine | both the expression level of SMO mRNA and SMO enzyme activity are significantly lower in breast cancer samples compared to nontumor samples | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
- |
Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
bis(ethyl)norspermine | structure modeling analysis of complex formed with SMO | Homo sapiens | |
bis(ethyl)norspermine | - |
Mus musculus | |
N,N' -bis(2,3-butadienyl)-1,4-butanediamine | i.e. MDL72527 | Mus musculus | |
N1-ethyl-N11-(cyclopropyl)-methyl-4,8-diazaundecane | structure modeling analysis of complex formed with SMO | Homo sapiens | |
N1-ethyl-N11-(cyclopropyl)-methyl-4,8-diazaundecane | - |
Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | - |
Homo sapiens | - |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.063 | - |
N,N' -bis(2,3-butadienyl)-1,4-butanediamine | pH 8.5, 25°C | Mus musculus | |
0.085 | - |
N1-ethyl-N11-(cyclopropyl)-methyl-4,8-diazaundecane | pH 8.5, 25°C | Mus musculus | |
0.38 | - |
bis(ethyl)norspermine | pH 8.5, 25°C | Mus musculus |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | both the expression level of SMO mRNA and SMO enzyme activity are significantly lower in breast cancer samples compared to nontumor samples | down |