Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.5.3.16 extracted from

  • Takao, K.; Shirahata, A.; Samejima, K.; Casero, R.A.; Igarashi, K.; Sugita, Y.
    Pentamines as substrate for human spermine oxidase (2013), Biol. Pharm. Bull., 36, 407-411.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene hSMO, expression in Escherichia coli strain BL21(DE3) Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
N1,N4-bis(2,3-butadienyl)-1,4 butanediamine i.e. MDL72527 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information Michaelis-Menten kinetics, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-
nucleus
-
Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
spermine + O2 + H2O Homo sapiens
-
spermidine + 3-aminopropanal + H2O2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
gene hSMO
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,16-diamino-4,8,13-triazahexadecane pentahydrochloride + O2 + H2O
-
Homo sapiens ?
-
?
additional information substrate activities of human spermine oxidase with various linear polyamines, overview. N1-acetyl-spermine is a poor substrate. H2O2 is measured by a HPLC method that analyzed fluorescent dimers derived from the oxidation of homovanillic acid in the presence of horseradish peroxidase Homo sapiens ?
-
?
N1-ethyl-spermine + O2 + H2O good substrate Homo sapiens spermidine + N-ethyl-3-aminopropanal + H2O2
-
?
spermine + O2 + H2O
-
Homo sapiens spermidine + 3-aminopropanal + H2O2
-
?
spermine + O2 + H2O preferred substrate Homo sapiens spermidine + 3-aminopropanal + H2O2
-
?

Synonyms

Synonyms Comment Organism
SMO
-
Homo sapiens
Spm oxidase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9
-
assay at Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
7 9 the activity markedly decreases from pH 9.0 to pH 7.0 Homo sapiens