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Literature summary for 1.5.3.7 extracted from

  • Natarajan, S.K.; Muthukrishnan, E.; Khalimonchuk, O.; Mott, J.L.; Becker, D.F.
    Evidence for pipecolate oxidase in mediating protection against hydrogen peroxide stress (2017), J. Cell. Biochem., 118, 1678-1688 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.5.3.7

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-pipecolate + O2 Homo sapiens pipecolate metabolism leads to protection against H2O2 stress in mammalian cells. The enzyme is necessary for pipecolate protection (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2
-
 ?
L-pipecolate + O2 Homo sapiens
-
 DELTA1-piperideine-6-carboxylate + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens Q9P0Z9
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-pipecolate + O2
-
 Homo sapiens (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2
-
 ?
L-pipecolate + O2 pipecolate metabolism leads to protection against H2O2 stress in mammalian cells. The enzyme is necessary for pipecolate protection Homo sapiens (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + H2O2
-
 ?
L-pipecolate + O2
-
 Homo sapiens DELTA1-piperideine-6-carboxylate + H2O2
-
 ?
L-proline + O2
-
 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 44000, calculated from amino acid sequence Homo sapiens

Synonyms

Synonyms Comment Organism
L-pipecolate oxidase
-
 Homo sapiens
PIPOX
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Homo sapiens
FAD flavoenzyme Homo sapiens

General Information

General Information Comment Organism
malfunction knockdown of the enzyme by small interference RNA abolishes pipecolate protection against hydrogen peroxide-induced cell death in HEK293 cells suggesting a critical role for this enzyme Homo sapiens
physiological function pipecolate metabolism leads to protection against H2O2 stress in mammalian cells. The enzyme is necessary for pipecolate protection Homo sapiens