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Literature summary for 1.5.99.14 extracted from

  • Shang, J.; Wang, X.; Zhang, M.; Wang, R.; Zhang, C.; Huang, H.; Wang, S.
    Rid enhances the 6-hydroxypseudooxynicotine dehydrogenase reaction in nicotine degradation by Agrobacterium tumefaciens S33 (2021), Appl. Environ. Microbiol., 87, e02769 .
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Agrobacterium tumefaciens
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Agrobacterium tumefaciens S33
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Synonyms

Synonyms Comment Organism
PNO
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Agrobacterium tumefaciens

General Information

General Information Comment Organism
physiological function Rid protein (participating in metabolite damage repair) encoded by a gene in the nicotine-degrading gene cluster enhances the reaction of 6-hydroxypseudooxynicotine dehydrogenase. Rid relieves the toxicity of the presumed imine intermediate produced in the 6-hydroxypseudooxynicotine dehydrogenase reaction and, in the presence of Rid, 6-hydroxypseudooxynicotine dehydrogenase maintains a high level of activity and the amount of the reaction product is increased by at least 5fold. Disruption of the Rid gene leads to slower growth on nicotine Agrobacterium tumefaciens