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Literature summary for 1.6.1.1 extracted from

  • Rydström, J.; Hoek, J.B.; Höjeberg, B.
    Ca 2+ -dependent allosteric regulation of nicotinamide nucleotide transhydrogenase from Pseudomonas aeruginosa (1973), Biochem. Biophys. Res. Commun., 52, 421-429.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
2'-AMP partially replaceable by 0.3 mM 2',3'-cyclic AMP or coenzyme A Pseudomonas aeruginosa
2'-AMP activation of NADP+ reduction by NADH is strongly Ca2+ dependent at nonsaturating concentrations of 2'-AMP Pseudomonas aeruginosa

Inhibitors

Inhibitors Comment Organism Structure
NADP+ inhibition in absence of Ca2+; strong inhibition in the absence of Ca2+, saturation with Ca2+ completely abolishes inhibition Pseudomonas aeruginosa

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
 Pseudomonas aeruginosa
K+ no full activation compared to Ca2+ Pseudomonas aeruginosa
Mg2+ no full activation even at saturation concentrations Pseudomonas aeruginosa
Mn2+ compared to Ca2+ 10 times higher concetrations are required to obtain the same degree of activation Pseudomonas aeruginosa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NADH + NADP+ Pseudomonas aeruginosa
-
 NADPH + NAD+
-
 ?

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADH + NADP+
-
 Pseudomonas aeruginosa NADPH + NAD+
-
 ?
NADP+ + NADH reduction of NADP+ is preferred Pseudomonas aeruginosa NADPH + NAD+
-
 r